Generic placeholder image

Anti-Cancer Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Polyhedral Boron Compounds as Potential Diagnostic and Therapeutic Antitumor Agents

Author(s): V. I. Bregadze, I. B. Sivaev and S. A. Glazun

Volume 6, Issue 2, 2006

Page: [75 - 109] Pages: 35

DOI: 10.2174/187152006776119180

Price: $65

Abstract

The use of polyhedral boron hydrides for cancer treatment is traditionally connected with boron neutron capture therapy. More recently, polyhedral borate anions were proposed as carriers of radionuclide label for targeted radionuclide therapy and diagnostics of cancer. Some metal derivatives of carboranes were found to demonstrate significant antitumor activity themselves. This review is designed to highlight the recent work concerning various fields of potential application of polyhedral boron compounds in anticancer diagnostics and therapy.

Keywords: Boron, carborane, borane, boron neutron capture therapy, radionuclides, anticancer drugs


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy