摘要
现代流感疫苗早已被用于抗击流感,但是,最近的进展强调新替代品的重要性。即使传统的流感疫苗是安全的,且通常是有效的,他们也需要每年上传来预防流感病毒的传播。这一限制和使用鸡胚作为疫苗生产的培养基,是耗时的,且可能牵涉生长新病毒株的潜在生物危害。原核微生物产生的质粒DNA和编码外源蛋白已经成为很有前途的治疗工具。这种技术通过真核细胞使目标基因进行表达,以诱导对目标病原体的保护性免疫反应。本文讨论了选择最佳的用于治疗和预防流感的核酸疫苗的策略。具体而言,我们更新了流感病毒核酸疫苗的发展、所有涉及的技术、其主要特点、适用性和技术特点,以获得对抗流感感染的最佳选择。
关键词: 基因表达,流感,流感感染,质粒DNA,纯化,疫苗。
Current Gene Therapy
Title:Influenza Plasmid DNA Vaccines: Progress and Prospects
Volume: 15 Issue: 6
Author(s): Diana Bicho, Joao Antonio Queiroz and Candida Teixeira Tomaz
Affiliation:
关键词: 基因表达,流感,流感感染,质粒DNA,纯化,疫苗。
摘要: Current influenza vaccines have long been used to fight flu infectious; however, recent advances highlight the importance of produce new alternatives. Even though traditional influenza vaccines are safe and usually effective, they need to be uploaded every year to anticipate circulating flu viruses. This limitation together with the use of embryonated chicken eggs as the substrate for vaccine production, is time-consuming and could involve potential biohazards in growth of new virus strains. Plasmid DNA produced by prokaryote microorganisms and encoding foreign proteins had emerged as a promising therapeutic tool. This technology allows the expression of a gene of interest by eukaryotic cells in order to induce protective immune responses against the pathogen of interest. In this review, we discuss the strategies to choose the best DNA vaccine to be applied in the treatment and prevention of influenza. Specifically, we give an update of influenza DNA vaccines developments, all involved techniques, their main characteristics, applicability and technical features to obtain the best option against influenza infections.
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Diana Bicho, Joao Antonio Queiroz and Candida Teixeira Tomaz , Influenza Plasmid DNA Vaccines: Progress and Prospects, Current Gene Therapy 2015; 15 (6) . https://dx.doi.org/10.2174/1566523215666150929111048
DOI https://dx.doi.org/10.2174/1566523215666150929111048 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
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