摘要
(ENPP2)也被称为自体毒素,是一种分泌溶血磷脂酶D,其水解溶血磷脂酰胆碱(LPC)成溶血磷脂酸(LPA)。LPA是ENPP2酶通过6 LPA-G-蛋白偶联受体(GPCR)诱导多种信号传导途径的生物活性产物。ENPP2为正常发展的重要蛋白质和其改变的表达与多种人类疾病有关。细胞的ENPP2沉默导致杀伤力在小鼠胚胎阶段。最初,它被鉴定为黑色素瘤细胞的自分泌因子。不同的研究小组目前正在探索理解ENPP2的各种处理,例如胚胎和神经发育,迁移,侵入,分化,增殖,血管生成和存活的多方面的作用。ENPP2的改变的表达也与各种疾病,如炎症,肿瘤,纤维化,类风湿性关节炎和神经缺陷有关。在本文中,我们总结ENPP2的结构方面,并与各种人类疾病,包括癌症和阿尔茨海默氏病(AD)的不同的细胞角色相关联的生化功能。此外,同时考虑与主张的调查结果,在各种植物化学物质和合成的抑制剂也提出目前探索作为靶向ENPP2函数关于各种人类疾病的治疗中的治疗剂的注释。
关键词: 核苷酸焦磷酸酯酶2,细胞增生,溶血磷脂酸,磷脂酶D
Current Molecular Medicine
Title:Understanding the Multifaceted Role of Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) and its Altered Behaviour in Human Diseases
Volume: 15 Issue: 10
Author(s): R. P. Cholia, H. Nayyar, R. Kumar and A. K. Mantha
Affiliation:
关键词: 核苷酸焦磷酸酯酶2,细胞增生,溶血磷脂酸,磷脂酶D
摘要: Ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2) also known as Autotaxin, is a secreted lysophospholipase D, which hydrolyzes lysophosphatidylcholine (LPC) into Lysophosphatidic acid (LPA). LPA is the bioactive product of ENPP2 enzyme, which induces diverse signalling pathways via six LPA-G-protein coupled receptors (GPCRs). ENPP2 is an essential protein for normal development and its altered expression is associated with various human diseases. Cellular ENPP2 silencing results in lethality at the embryonic stage in mice. Initially, it is identified as an autocrine factor in melanoma cells. Different research groups are currently exploring to understand the multifaceted role of ENPP2 in various processes such as embryonic and neural development, migration, invasion, differentiation, proliferation, angiogenesis, and survival. Altered expression of ENPP2 is also associated with various diseases like inflammation, cancer, fibrosis, rheumatoid arthritis and neural defects. In this article, we have summarized structural aspects of ENPP2 and biochemical functions associated with its diverse cellular roles in various human diseases including cancer and Alzheimer’s disease (AD). In addition, keeping in view and advocating findings, a note on various phytochemicals and synthetic inhibitors, which are currently explored as therapeutic agents targeting functions of ENPP2 for the treatment of various human diseases is also presented.
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R. P. Cholia, H. Nayyar, R. Kumar and A. K. Mantha , Understanding the Multifaceted Role of Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) and its Altered Behaviour in Human Diseases, Current Molecular Medicine 2015; 15 (10) . https://dx.doi.org/10.2174/1566524015666150921104804
DOI https://dx.doi.org/10.2174/1566524015666150921104804 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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