一氧化氮在神经退行性疾病中的动态平衡

Title:Nitric Oxide Homeostasis in Neurodegenerative Diseases

Volume: 13 Issue: 2

Author(s): Luciana Hannibal

Affiliation:

关键词: 阿尔茨海默病，蛋白质相互作用，金属平衡，神经退行性疾病，一氧化氮，一氧化氮合酶，氧化应激，蛋白质组学。

摘要: The role of nitric oxide in the pathogenesis and progression of neurodegenerative illnesses such as Parkinson’s and Alzheimer’s diseases has become prominent over the years. Increased activity of the enzymes that produce reactive oxygen species, decreased activity of antioxidant enzymes and imbalances in glutathione pools mediate and mark the neurodegenerative process. Much of the oxidative damage of proteins is brought about by the overproduction of nitric oxide by nitric oxide synthases (NOS) and its subsequent reactivity with reactive oxygen species. Proteomic methods have advanced the field tremendously, by facilitating the quantitative assessment of differential expression patterns and oxidative modifications of proteins and alongside, mapping their non-canonical functions. As a signaling molecule involved in multiple biochemical pathways, the level of nitric oxide is subject to tight regulation. All three NOS isoforms display aberrant patterns of expression in Alzheimer’s disease, altering intracellular signaling and routing oxidative stress in directions that are uncompounded. This review discusses the prime factors that control nitric oxide biosynthesis, reactivity footprints and ensuing effects in the development of neurodegenerative diseases.

Cite this article as:

Luciana Hannibal , Nitric Oxide Homeostasis in Neurodegenerative Diseases, Current Alzheimer Research 2016; 13 (2) . https://dx.doi.org/10.2174/1567205012666150921101250