Value Assignment Study on a New Certified Reference Material of Cyclovirobuxine D by Differential Scanning Calorimetry Method

Title:Value Assignment Study on a New Certified Reference Material of Cyclovirobuxine D by Differential Scanning Calorimetry Method

Volume: 12 Issue: 6

Author(s): Li Zhang, Yang Lu, Yonghui Guo, Wei Xu, Guimin Jin and Guanhua Du

Affiliation:

Keywords: Cyclovirobuxine D, DSC, value assignment, uncertainty evaluation, CRM, homogeneity study, stability study.

Abstract: Cyclovirobuxine D is an active steroid alkaloid distributed in Buxus microphylla and applied in therapeutic practice of cardiovascular disease. This study describes the development of a new CRM, which includes the homogeneity assessment, stability assessment, purity determination, and uncertainty evaluation. DSC method was applied to the value assignment of cyclovirobuxine D for the first time. The certified purity value for the CRM of cyclovirobuxine D is 996.6 mg•g-1 with an extended uncertainty of 0.6 mg•g-1 (k = 2, P = 0.95) by DSC method. The CRM of cyclovirobuxine D can be widely used to quantitative analyses of cyclovirobuxine D and other related pharmaceutical formulations.

Cite this article as:

Zhang Li, Lu Yang, Guo Yonghui, Xu Wei, Jin Guimin and Du Guanhua, Value Assignment Study on a New Certified Reference Material of Cyclovirobuxine D by Differential Scanning Calorimetry Method, Current Analytical Chemistry 2016; 12 (6) . https://dx.doi.org/10.2174/1573411011666150918190217