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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

An Efficient Three-Component Reaction of Sodium Azide, Haloalkane and Alkyne for the Synthesis of 1, 2, 3-Triazoles Catalyzed by the Bifunctional Ionic Liquid Catalyst Choline Chloride-CuCl in Water

Author(s): Xuan-Gan Liu, Xian-Liang Zhao, Yan Zhang and Jian-Rong Gao

Volume 13, Issue 3, 2016

Page: [224 - 230] Pages: 7

DOI: 10.2174/1570178612666150908213423

Price: $65

Abstract

1, 2, 3-Triazoles were synthesized using a one-pot procedure via a threecomponent reaction between an organic halide, sodium azide and alkyne in the presence of an ionic liquid choline chloride-CuCl catalyst. The catalyst can increase the rate of the nucleophilic substitution reaction and showed a high catalytic activity for the [3+2] Huisgen cycloaddition in water. This method is applicable for a wide range of alkynes including aromatic and heterocyclic substrates.

Keywords: Aqueous media, choline chloride, CuCl, cycloaddition, ionic liquid catalyst, three-component.

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