Nutritional Status and Lipid Profile in HIV-Infected Adults

Title:Nutritional Status and Lipid Profile in HIV-Infected Adults

Volume: 15 Issue: 4

Author(s): M. Stambullian, M. S. Feliu, L. I. Cassetti and N. H. Slobodianik

Affiliation:

Keywords: Adults, apolipoprotein B, HIV infection, lipids, non-HDL cholesterol, obesity, overweight.

Abstract: In the last decades, there have been many reports of HIV infection and abnormalities in lipid metabolism and cardiovascular disease (CVD). This study aims at describing the nutritional status of HIV-infected adults and its relation to lipid profile through traditional [total cholesterol (TC), HDL cholesterol (HDL), triglycerides (TG), non-HDL cholesterol and LDL cholesterol (LDL)] and other parameters [Apolipoprotein B (ApoB), fibrinogen, and high sensitive-C-reactive protein (hs-CRP)].

A cross-sectional descriptive study was performed. Body mass index (BMI) was calculated and references were taken from WHO. TC, HDL, TG and glucose were determined and non-HDL cholesterol and LDL were calculated. ApoB and fibrinogen were determined by quantitative radial immunodiffusion on agar plates (Diffuplate,Biocientífica SA,Argentina) and hs-CRP by immunoturbidimetric test. Qualitative variables were compared with the Chi-square test or Fisher's exact test. Quantitative variables were compared applying parametrics or nonparametric tests. Pearson test for correlations. Software SPSS 17.0. 97 patients were analyzed: 69.1% were men. 80% were on antiretroviral treatment. Average (SD) BMI was 24.3 (4.1) kg/m². 29.4% were overweight and 5.9% obese. Patients with a BMI ≥25.0 kg/m² presented significantly higher levels of TG, ApoB and glycemia than well-nourished people [246.1(169.0) vs. 142.9(78.4) mg/dL;p=0.029, 198.6(69.3) vs. 126.4(50.6) mg/dL;p=0.01 and 100 (3.2) vs. 90.2 (6.9) mg/dL;p=0.008 resp.] and a significantly decreased HDL [37.2(1.5) vs. 49.8(10.4) mg/dL;p<0.01]. No statistically significant correlation was found between ApoB and non-HDL (p=0,063). There was no evidence that there is a direct relation between Apo B and the other lipid parameters. The potential increase in CVD in this group of patients, would be related to the higher levels of TG, ApoB and overweight/obesity. Nutritional education is needed to promote a healthy weight to warn against the risk of cardiovascular disease.

Cite this article as:

Stambullian M., Feliu S. M., Cassetti I. L. and Slobodianik H. N., Nutritional Status and Lipid Profile in HIV-Infected Adults, Endocrine, Metabolic & Immune Disorders - Drug Targets 2015; 15 (4) . https://dx.doi.org/10.2174/1871530315666150907111120