Synthesis, Molecular Structure and Spectral Properties of New Aminosteroid Analogs of Squalamine Derivatives

Title:Synthesis, Molecular Structure and Spectral Properties of New Aminosteroid Analogs of Squalamine Derivatives

Volume: 12 Issue: 9

Author(s): Tomasz Pospieszny, Hanna Koenig, Iwona Kowalczyk and Bogumil Brycki

Affiliation:

Keywords: Bile acids, PM5 calculations, quaternary alkylammonium salts, spectral analysis, tertiary alkylamine.

Abstract: New quaternary alkylammonium conjugates of steroids were obtained by two step reaction of methyl esters of bile acids with bromoacetic acid bromide, followed by bimolecular nucleophilic substitution with a long chain tertiary alkylamine. The structures of products were conrmed by spectroscopic (¹H-NMR, ¹³C-NMR, and FT-IR) analysis, mass spectrometry (ESI-MS) as well as PM5 semiempirical methods. The biological activity of the synthesized compounds has been estimated on the basis of Prediction of Activity Spectra for Substances (PASS).

Cite this article as:

Pospieszny Tomasz, Koenig Hanna, Kowalczyk Iwona and Brycki Bogumil, Synthesis, Molecular Structure and Spectral Properties of New Aminosteroid Analogs of Squalamine Derivatives, Letters in Organic Chemistry 2015; 12 (9) . https://dx.doi.org/10.2174/1570178612666150902235216