Nanoemulsion-based Parenteral Drug Delivery System of Carbamazepine: Preparation, Characterization, Stability Evaluation and Blood-Brain Pharmacokinetics

Title:Nanoemulsion-based Parenteral Drug Delivery System of Carbamazepine: Preparation, Characterization, Stability Evaluation and Blood-Brain Pharmacokinetics

Volume: 12 Issue: 6

Author(s): Sim Ling Tan, Johnson Stanslas, Mahiran Basri, Abedi Karjiban R.A., Brian P. Kirby, Dahiru Sani and Hamidon Bin Basri

Affiliation:

Keywords: Blood-brain pharmacokinetics, Characterization, Oil-in-water nanoemulsion, stability evaluation, parenteral.

Abstract: Carbamzepine (CBZ) was encapsulated in a parenteral oil-in-water nanoemulsion, in an attempt to improve its bioavailability. The particle size, polydispersity index and zeta potential were measured using dynamic light scattering. Other parameters such as pH, osmolality, viscosity, drug loading efficiency and entrapment efficiency were also recorded. Transmission electron microscopy revealed that emulsion droplets were almost spherical in shape and in the nano-range. The in vitro release profile was best characterized by Higuchi’s equation. The parenteral nanoemulsion of CBZ showed significantly higher AUC_0→5, AUC_0→∞, AUMC_0→5, AUMC_0→∞, C_max and lower clearance than that of CBZ solution in plasma. Additionally, parenteral nanoemulsion of CBZ showed significantly higher AUC_0→∞, AUMC_0→∞ and C_maxthan that of CBZ solution in brain. The parenteral nanoemulsion of CBZ could therefore use as a carrier, worth exploring further for brain targeting.

Cite this article as:

Tan Ling Sim, Stanslas Johnson, Basri Mahiran, Karjiban R.A. Abedi, Kirby P. Brian, Sani Dahiru and Basri Bin Hamidon, Nanoemulsion-based Parenteral Drug Delivery System of Carbamazepine: Preparation, Characterization, Stability Evaluation and Blood-Brain Pharmacokinetics, Current Drug Delivery 2015; 12 (6) . https://dx.doi.org/10.2174/1567201812666150901112544