Abstract
The aldol reactions catalyzed by aldolases are an important tool in the synthesis of different products or building blocks. However, despite its advantages, aldolases, as enzymes, have some troubles as their low activity against synthetic substrates or the low stability, doing difficult their application. There are different tools to improve the properties of this enzyme such as directed mutagenesis, directed evolution or the immobilization methods. The immobilization not only is able to improve the properties of the enzymes but also permits the reuse of the catalysts. This review is focused on the immobilization of different aldolases using different methodologies.
Keywords: Aldolase, enzyme immobilization, solid supports.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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