Abstract
Phytochemical investigation on the methanol extract of Phyllanthus myrtifolius leaves led to the isolation of a new oleanan derivative, 3β-(3’,4’-di-O-acetyl-α-L-arabinopyranosyl)-12-oleanen- 28-oic acid (1). The structure of compound 1 was determined mainly by extensive NMR data analysis. Together with this compound, six arylnaphtalene lignans 2–7 were also isolated and identified. The isolated compounds 1–7 were tested for their antibacterial activities against eight pathogenic bacteria, showing that compound 1 exhibited highest activity.
Keywords: Antibacterial, euphorbiaceae, lignans, oleanane, Phyllanthus myrtifolius, triterpene.
The Natural Products Journal
Title:An Acetylated Triterpene Glycoside and Lignans from Phyllanthus myrtifolius and their Antibacterial Activities
Volume: 5 Issue: 3
Author(s): Neneng Windayani, Lia D. Juliawaty, Euis H. Hakim, Komar Ruslan and Yana M. Syah
Affiliation:
Keywords: Antibacterial, euphorbiaceae, lignans, oleanane, Phyllanthus myrtifolius, triterpene.
Abstract: Phytochemical investigation on the methanol extract of Phyllanthus myrtifolius leaves led to the isolation of a new oleanan derivative, 3β-(3’,4’-di-O-acetyl-α-L-arabinopyranosyl)-12-oleanen- 28-oic acid (1). The structure of compound 1 was determined mainly by extensive NMR data analysis. Together with this compound, six arylnaphtalene lignans 2–7 were also isolated and identified. The isolated compounds 1–7 were tested for their antibacterial activities against eight pathogenic bacteria, showing that compound 1 exhibited highest activity.
Export Options
About this article
Cite this article as:
Windayani Neneng, Juliawaty D. Lia, Hakim H. Euis, Ruslan Komar and Syah M. Yana, An Acetylated Triterpene Glycoside and Lignans from Phyllanthus myrtifolius and their Antibacterial Activities, The Natural Products Journal 2015; 5 (3) . https://dx.doi.org/10.2174/2210315505666150827213538
DOI https://dx.doi.org/10.2174/2210315505666150827213538 |
Print ISSN 2210-3155 |
Publisher Name Bentham Science Publisher |
Online ISSN 2210-3163 |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Meet Our Editorial Board Member
Infectious Disorders - Drug Targets Targeting Strategies in Therapeutic Applications of Toxoplasmosis: Recent Advances in Liposomal Vaccine Delivery Systems
Current Drug Targets Multifocal Osteolytic Lesions in Skull Bone with Mycobacterium <i>Tuberculosis</i>: A Case Report
Infectious Disorders - Drug Targets The IL-17 Family of Cytokines - Applications in Respiratory Medicine and Allergology
Recent Patents on Inflammation & Allergy Drug Discovery Anti-Inflammatory Properties of Drugs from saffron crocus
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Synthesis and Anti-cancer Activities of Apigenin Derivatives
Medicinal Chemistry Fracture Risk Associated with Use of Antibiotics
Current Drug Safety Cheminformatics Based Machine Learning Approaches for Assessing Glycolytic Pathway Antagonists of Mycobacterium tuberculosis
Combinatorial Chemistry & High Throughput Screening Renaissance in Antibiotic Discovery: Some Novel Approaches for Finding Drugs to Treat Bad Bugs
Current Medicinal Chemistry Trace and Minor Element Concentrations in Aqueous Extract of the Herbal Medicinal Plants Tamarindus indica and Hibiscus sabdiffora
Current Nutrition & Food Science Benzothiazol Clubbed Imidazol-4-ones as Anti-fungal, Anti-tubercular and Anti-HIV-1 Agents: Their Synthesis and Molecular Docking Study
Letters in Drug Design & Discovery Evaluation of Various Diagnostic Techniques for the Diagnosis of Pulmonary and Extra Pulmonary Tuberculosis at a Tertiary Care Center in North India
Infectious Disorders - Drug Targets The Balancing Act between Colonisers and Inflammation: T regulatory and TH17 Cells in Mucosal Immunity during Otitis Media
Current Immunology Reviews (Discontinued) Laccase Regulators in Anti-fungal Drug Discovery: Dark Lessons from the AIDS-related Pathogen, Cryptococcus
Current Enzyme Inhibition The Immune-Endocrine-Metabolic Unit During Human Tuberculosis
Current Immunology Reviews (Discontinued) Bactericidal Activity of Usnic Acid-Loaded Electrospun Fibers
Recent Patents on Nanotechnology Proteome Analysis Revealed Jak/Stat Signaling and Cytoskeleton Rearrangement Proteins in Human Lung Epithelial Cells During Interaction with Aspergillus terreus
Current Signal Transduction Therapy Editorial (Mucosal Co-Infections and HIV-1 Transmission and Pathogenesis)
Current HIV Research Design, Synthesis and Evaluation of Antimicrobial Activity of Novel Oxazine Derivatives using Betti’s Protocol
Letters in Drug Design & Discovery Lactosylceramide is a Pattern Recognition Receptor that Forms Lyn-Coupled Membrane Microdomains on Neutrophils
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued)