Abstract
The discovery of the selective delta (δ) opioid agonists SNC 80 and BW373U86, which possess a diarylmethylpiperazine structure unique among opioids, was a major advance in the field of δ-opioid ligands. Much research has been performed to uncover the structure-activity relationships (SAR) of this class of ligands and also to compare the diarylmethylpiperazines with the traditional morphinan-based d opioids. This review focuses on the development of the SAR of this unique series of ligands, and discusses questions which remain unanswered.
Keywords: diarylmethylpiperazine, BW373U86
Current Pharmaceutical Design
Title: SNC 80 and Related δ Opioid Agonists
Volume: 10 Issue: 7
Author(s): S. N. Calderon and A. Coop
Affiliation:
Keywords: diarylmethylpiperazine, BW373U86
Abstract: The discovery of the selective delta (δ) opioid agonists SNC 80 and BW373U86, which possess a diarylmethylpiperazine structure unique among opioids, was a major advance in the field of δ-opioid ligands. Much research has been performed to uncover the structure-activity relationships (SAR) of this class of ligands and also to compare the diarylmethylpiperazines with the traditional morphinan-based d opioids. This review focuses on the development of the SAR of this unique series of ligands, and discusses questions which remain unanswered.
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Cite this article as:
Calderon N. S. and Coop A., SNC 80 and Related δ Opioid Agonists, Current Pharmaceutical Design 2004; 10 (7) . https://dx.doi.org/10.2174/1381612043453054
DOI https://dx.doi.org/10.2174/1381612043453054 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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