非甾体抗炎药除了是环氧合酶抑制剂外的有效预防结肠癌的作用。

Title:Non Steroidal Anti Inflammatory Drugs As Gatekeepers Of Colon Carcinoma Highlight New Scenarios Beyond Cyclooxygenases Inhibition

Volume: 16 Issue: 2

Author(s): Tiziana Guarnieri

Affiliation:

关键词: 结肠癌，炎症，非甾体抗炎药，增殖，转录因子，肿瘤。

摘要: Epidemiological data suggest that Non Steroidal Anti Inflammatory Drugs (NSAIDs) and Cyclooxygenase 2 (COX2) inhibitors (COXibs) can exert chemopreventive and antitumour effects in many human neoplasia. This is particularly true in colon cancer (CC), where the regular assumption of these molecules has been shown to exert chemopreventive and chemotherapeutic effects. Since the late ‘90s, there has been a progressive increase in experimental evidence, indicating that in CC the antiproliferative effects of NSAIDs and COXibs could be both dependent on and independent of COXs inhibition, and that these effects do not necessarily exclude each other. This review will examine some of these COX-independent cellular pathways, with a focus on those involved in the inhibition of CC cells proliferation through transcription factors crosstalk.

Cite this article as:

Tiziana Guarnieri , Non Steroidal Anti Inflammatory Drugs As Gatekeepers Of Colon Carcinoma Highlight New Scenarios Beyond Cyclooxygenases Inhibition, Current Cancer Drug Targets 2016; 16 (2) . https://dx.doi.org/10.2174/1568009615666150827093012