嵌合抗原受体T细胞：癌症的自我复制药物

Title:Chimeric Antigen Receptor T Cells: Self-Replicating Drugs for Cancer

Volume: 18 Issue: 3

Author(s): Jan J. Melenhorst, Simon F. Lacey, Felipe Bedoya.

Affiliation:

关键词: 细胞治疗，嵌合抗原受体（CAR），基因治疗，合成生物学

摘要: The chimeric antigen receptor (CAR) technology started out as a tool to understand lymphocyte biology but rapidly developed into a T cell therapeutic agent for the treatment of cancers. Here, we describe the technological advances in the field of CARs and highlight critical components of its success. Additionally, we describe how various laboratories have worked toward developing new, safer, and more potent CARs for cancer.

Cite this article as:

Jan J. Melenhorst, Simon F. Lacey, Felipe Bedoya. , Chimeric Antigen Receptor T Cells: Self-Replicating Drugs for Cancer, Current Drug Targets 2017; 18 (3) . https://dx.doi.org/10.2174/1389450116666150825120427