摘要
嵌合抗原受体(CAR)技术开始作为一种工具,了解淋巴细胞生物学,但迅速发展成T细胞治疗剂用于治疗癌症。在这里,我们描述了嵌合抗原受体领域的技术进步,并强调其成功的关键组成部分。此外,我们描述了如何各种实验室都致力于开发新的,更安全,更强大的嵌合抗原受体治疗癌症。
关键词: 细胞治疗,嵌合抗原受体(CAR),基因治疗,合成生物学
图形摘要
Current Drug Targets
Title:Chimeric Antigen Receptor T Cells: Self-Replicating Drugs for Cancer
Volume: 18 Issue: 3
Author(s): Jan J. Melenhorst, Simon F. Lacey, Felipe Bedoya.
Affiliation:
关键词: 细胞治疗,嵌合抗原受体(CAR),基因治疗,合成生物学
摘要: The chimeric antigen receptor (CAR) technology started out as a tool to understand lymphocyte biology but rapidly developed into a T cell therapeutic agent for the treatment of cancers. Here, we describe the technological advances in the field of CARs and highlight critical components of its success. Additionally, we describe how various laboratories have worked toward developing new, safer, and more potent CARs for cancer.
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Cite this article as:
Jan J. Melenhorst, Simon F. Lacey, Felipe Bedoya. , Chimeric Antigen Receptor T Cells: Self-Replicating Drugs for Cancer, Current Drug Targets 2017; 18 (3) . https://dx.doi.org/10.2174/1389450116666150825120427
DOI https://dx.doi.org/10.2174/1389450116666150825120427 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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