D类碳青烯酶的构效关系

Title:Structure-Function Relationships of Class D Carbapenemases

Volume: 17 Issue: 9

Author(s): Jean-Denis Docquier, Stefano Mangani

Affiliation:

关键词: 抗生素耐药性；碳青霉烯类；β-内酰胺酶；肺炎克雷伯菌；鲍曼不动杆菌

摘要: Class D carbapenemases, also known as Carbapenem-Hydrolyzing class D β-Lactamases (CHDLs) are of increasingly high clinical relevance, as they have been found in various important human pathogens, such as Acinetobacter baumannii and Klebsiella pneumoniae and contribute to the evolution of these pathogens towards extensively or totally-drug resistance (XDR/TDR) phenotypes. Essentially two main groups of phylogenetically-related enzymes have been described: one including the acquired OXA-23, OXA-24/40, OXA-51 and OXA-58 enzymes mostly in Acinetobacter baumannii, and the other including the OXA-48-related variants, i.e. OXA-54, OXA-162, OXA-163 and OXA- 181. In this article, the biochemical and structural features of class D carbapenemases will be discussed. Furthermore, the mechanistic hypothesis based on recently obtained crystal structures of the native forms of class D carbapenemases and mutants thereof, in complex with relevant substrates or inhibitors, will be critically reviewed. Finally, the mechanism of inhibition by available inhibitors, some of which are currently in clinical development, will be discussed.

Cite this article as:

Jean-Denis Docquier, Stefano Mangani , Structure-Function Relationships of Class D Carbapenemases, Current Drug Targets 2016; 17 (9) . https://dx.doi.org/10.2174/1389450116666150825115824