摘要
胆管癌(CCA)是影响胆道上皮的异质性发育障碍组。它是第二常见的原发性肝肿瘤,占所有胃肠癌的3%左右。由于其积极性,晚期诊断和高耐化学性,CCA非常致命。全球的发病率正在增加,治疗方案非常有限。放射治疗,化疗,手术和/或肝移植可能在符合某些标准的患者中显示,但成功率很低。因此,越来越有兴趣了解参与这种癌症类型的发病机理的分子机制以及鉴定新的治疗靶标。目前的策略是基于涉及增殖,存活,凋亡和迁移的关键信号通路。在这篇综述中,讨论了涉及CCA发病机制的最相关的分子机制,并强调了主要的临床前和临床研究。此外,还指出了基础和临床研究的未来发展方向。
关键词: 胆道上皮,胆管癌,癌症,发病机制,基质,分子机制,治疗
图形摘要
Current Drug Targets
Title:Molecular Mechanisms of Cholangiocarcinogenesis: New Potential Targets for Therapy
Volume: 18 Issue: 8
关键词: 胆道上皮,胆管癌,癌症,发病机制,基质,分子机制,治疗
摘要: Cholangiocarcinoma (CCA) is a heterogeneous group of dysplastic disorders affecting the biliary epithelium. It is the second most common primary liver tumor which accounts for around 3% of all gastrointestinal cancers. CCA is very deadly due to its aggressiveness, late diagnosis and high chemoresistance. The incidence is increasing worldwide and the therapeutic options are very limited. Radiotherapy, chemotherapy, surgery and/or liver transplantation may be indicated in patients who meet certain criteria, but chances of success are low. There is therefore increasing interest in understanding the molecular mechanisms involved in the pathogenesis of this cancer type and in identifying new targets for therapy. Current strategies are based on targeting key signaling pathways involved in proliferation, survival, apoptosis and migration. In this review, the most relevant molecular mechanisms involved in the pathogenesis of CCA are discussed and the main preclinical and clinical studies are highlighted. Moreover, future directions in basic and clinical research are indicated.
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Molecular Mechanisms of Cholangiocarcinogenesis: New Potential Targets for Therapy, Current Drug Targets 2017; 18 (8) . https://dx.doi.org/10.2174/1389450116666150825113035
DOI https://dx.doi.org/10.2174/1389450116666150825113035 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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