发生胆管癌的分子机制：治疗的新潜在靶点

Title:Molecular Mechanisms of Cholangiocarcinogenesis: New Potential Targets for Therapy

Volume: 18 Issue: 8

关键词: 胆道上皮，胆管癌，癌症，发病机制，基质，分子机制，治疗

摘要: Cholangiocarcinoma (CCA) is a heterogeneous group of dysplastic disorders affecting the biliary epithelium. It is the second most common primary liver tumor which accounts for around 3% of all gastrointestinal cancers. CCA is very deadly due to its aggressiveness, late diagnosis and high chemoresistance. The incidence is increasing worldwide and the therapeutic options are very limited. Radiotherapy, chemotherapy, surgery and/or liver transplantation may be indicated in patients who meet certain criteria, but chances of success are low. There is therefore increasing interest in understanding the molecular mechanisms involved in the pathogenesis of this cancer type and in identifying new targets for therapy. Current strategies are based on targeting key signaling pathways involved in proliferation, survival, apoptosis and migration. In this review, the most relevant molecular mechanisms involved in the pathogenesis of CCA are discussed and the main preclinical and clinical studies are highlighted. Moreover, future directions in basic and clinical research are indicated.

Cite this article as:

Molecular Mechanisms of Cholangiocarcinogenesis: New Potential Targets for Therapy, Current Drug Targets 2017; 18 (8) . https://dx.doi.org/10.2174/1389450116666150825113035