摘要
在胃肠道肿瘤治疗的基础上,提供了越来越多对癌症的发病机制有针对性的正在开发的分子生物学治疗的知识。确切地说,有针对性的治疗被定义为一种“类型的治疗,使用药物,如单克隆抗体或酪氨酸激酶抑制剂,以识别和攻击特定的癌细胞”。现在,美国食品和药品管理局已经批准了许多有针对性的治疗胃肠道肿瘤的治疗,与此同时,许多是在不同阶段的发展。在以前的研究中,我们讨论了用于胃肠道肿瘤的研究主要的单克隆抗体。除了单克隆抗体、酪氨酸激酶抑制剂代表另一类靶向治疗和伊马替尼治疗胃肠道间质瘤,其他酪氨酸激酶抑制剂已被批准用于治疗胃肠道肿瘤,如舒尼替尼,索拉非尼和厄洛替尼。更长远来说,这篇评论的目的是专注于用于每个胃肠道肿瘤的个性化治疗的常用的酪氨酸激酶抑制剂的治疗,并提供一个建立在正在进行的实验靶向治疗的全面概述。
关键词: 批准的酪氨酸激酶抑制剂,疗效数据,实验酪氨酸激酶抑制剂,胃肠道肿瘤,个性化治疗。
Current Cancer Drug Targets
Title:Old Tyrosine Kinase Inhibitors and Newcomers in Gastrointestinal Cancer Treatment
Volume: 16 Issue: 2
Author(s): Giordani Erika, Zoratto Federica, Strudel Martina, Papa Anselmo, Rossi Luigi, Minozzi Marina and Caruso Davide, Zaccarelli Eleonora, Verrico Monica and Tomao Silverio
Affiliation:
关键词: 批准的酪氨酸激酶抑制剂,疗效数据,实验酪氨酸激酶抑制剂,胃肠道肿瘤,个性化治疗。
摘要: Gastrointestinal cancer treatment is based more on molecular biology that has provided increasing knowledge about cancer pathogenesis on which targeted therapy is being developed. Precisely, targeted therapy is defined as a “type of treatment that uses drugs, such as monoclonal antibodies or tyrosine kinase inhibitors, to identify and attack specific cancer cells”. Nowadays, the United States Food and Drug Administration has approved many targeted therapies for gastrointestinal cancer treatment, as many are in various phases of development as well. In a previous review we discussed the main monoclonal antibodies used and studied in gastrointestinal cancer. In addition to monoclonal antibodies, tyrosine kinase inhibitors represent another class of targeted therapy and following the approval of imatinib for gastrointestinal stromal tumours, other tyrosine kinase inhibitors have been approved for gastrointestinal cancers treatment such as sunitinib, regoragenib, sorafenib and erlotinib. Moving forward, the purpose of this review is to focus on the efficacy data of main tyrosine kinase inhibitors commonly used in the personalized treatment of each gastrointestinal tumour and to provide a comprehensive overview about experimental targeted therapies ongoing in this setting.
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Giordani Erika, Zoratto Federica, Strudel Martina, Papa Anselmo, Rossi Luigi, Minozzi Marina and Caruso Davide, Zaccarelli Eleonora, Verrico Monica and Tomao Silverio , Old Tyrosine Kinase Inhibitors and Newcomers in Gastrointestinal Cancer Treatment, Current Cancer Drug Targets 2016; 16 (2) . https://dx.doi.org/10.2174/1568009615666150817120712
DOI https://dx.doi.org/10.2174/1568009615666150817120712 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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