摘要
急性髓系白血病(AML)是一种高度恶性克隆性造血障碍疾病,过去几十年其治疗方案一直不变。虽然传统的化疗方式在治愈AML患者方面具有潜力,但病程往往致命,故需突出新的治疗理念。在基因技术的进展显著地促进了我们对导致疾病的分子机制的了解,但这些进展并未在改善治疗效果方面获得成功。本文将对一些白血病细胞表达有前途的靶点进行阐述,包括白血病干/祖细胞维护和耐药性方面所关联的重要信号转导通路。本文还将讨论临床前和临床治疗中新的治疗靶点,因此,集中于新化合物靶向受体和非受体酪氨酸激酶,法尼基转移酶蛋白,和表观遗传修饰等的概述。
关键词: 急性髓细胞性白血病,白血病干细胞化疗,信号途径。
Current Cancer Drug Targets
Title:Signal transduction in Acute Myeloid Leukemia – Implications for Novel Therapeutic Concepts.
Volume: 15 Issue: 9
Author(s): Heiko Konig and Cedric Dos Santos
Affiliation:
关键词: 急性髓细胞性白血病,白血病干细胞化疗,信号途径。
摘要: Acute Myeloid Leukemia (AML) is a highly aggressive clonal hematopoietic disorder that has been managed with largely unchanged treatment protocols for the past decades. Although conventional chemotherapy bears the potential to cure some AML patients, the course of the disease is frequently fatal despite treatment highlighting the need for novel therapeutic concepts. Recent progress in genetic technologies significantly furthered our understanding of the molecular events leading to the disease, but these advances have not yet been successfully translated into improved treatment outcomes. Here, we review some of the new promising targets expressed by leukemic blasts, including important signaling pathways involved in AML stem/progenitor cell maintenance and drug resistance. We furthermore discuss novel targeted therapies in pre-clinical and clinical development thereby focusing on new compounds targeting receptor and non-receptor tyrosine kinases, farnesyltransferase proteins, and epigenetic modifiers.
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Cite this article as:
Heiko Konig and Cedric Dos Santos , Signal transduction in Acute Myeloid Leukemia – Implications for Novel Therapeutic Concepts., Current Cancer Drug Targets 2015; 15 (9) . https://dx.doi.org/10.2174/1568009615666150817104916
DOI https://dx.doi.org/10.2174/1568009615666150817104916 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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