摘要
叶酸(FA)对三种叶酸受体(FRS)亚型具有高亲和力,分别是:FRα、FRβ和FRγ。其中,FRα是肿瘤特异性受体,它在各种肿瘤中经常过表达而在正常组织中不表达。在这项研究中,我们结合叶酸到一种壳聚糖聚(乙烯亚胺)共聚物中,并证实了该产品(即“CP1.3K-FA”)在肿瘤细胞中的低细胞毒性。转染发实验证明,在最佳条件下,对CP1.3K-FA转染效率高于未改性的壳聚糖聚(乙烯亚胺)共聚物。荧光素酶活性检测结果也表明,CP1.3K-FA转染效率可以与B16和U87细胞中的Fugene HD相比较。我们的研究结果表明,CP1.3K-FA将进一步发展为肿瘤细胞基因传递的载体
关键词: 壳聚糖,叶酸,基因转移,非病毒载体,聚(乙烯亚胺),靶向。
Current Gene Therapy
Title:Folate-conjugated Chitosan-poly(ethylenimine) Copolymer As An Efficient and Safe Vector For Gene Delivery in Cancer Cells
Volume: 15 Issue: 5
Author(s): Wing-Fu Lai and Marie C. Lin
Affiliation:
关键词: 壳聚糖,叶酸,基因转移,非病毒载体,聚(乙烯亚胺),靶向。
摘要: Folic acid (FA) has high affinity to folate receptors (FRs), which have three isoforms: FRα, FRβ and FRγ. Among them, FRα is a tumor specific receptor, as it is frequently over-expressed in diverse malignancies but not in normal tissues. In this study, we have conjugated FA to a chitosan-poly(ethylenimine) copolymer, and have confirmed the low cytotoxicity of the product (namely “CP1.3K-FA”) in cancer cells. The transfection efficiency of CP1.3K-FA has been shown by the EGFP transfection assay to be higher than that of the unmodified chitosan-poly(ethylenimine) copolymer under optimal conditions. Results of the luciferase activity assay have also indicated that the transfection efficiency of CP1.3K-FA is comparable to that of Fugene HD in B16 and U87 cells. Our results have suggested that CP1.3K-FA warrants further development as a vector for gene delivery in cancer cells.
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Lai Wing-Fu and Lin C. Marie, Folate-conjugated Chitosan-poly(ethylenimine) Copolymer As An Efficient and Safe Vector For Gene Delivery in Cancer Cells, Current Gene Therapy 2015; 15 (5) . https://dx.doi.org/10.2174/1566523215666150812120347
DOI https://dx.doi.org/10.2174/1566523215666150812120347 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
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