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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Nano-Structured Pyrophosphate Na2CaP2O7 as Catalyst for Selective Synthesis of 1,2-Disubstituted Benzimidazoles in Pure Water

Author(s): Karim Dänoun, Ilham Jioui, Mohamed Bouhrara, Mohamed Zahouily, Abderrahim Solhy, Mustapha Jouiad, Christophe Len and Aziz Fihri

Volume 19, Issue 21, 2015

Page: [2132 - 2140] Pages: 9

DOI: 10.2174/1385272819666150807190728

Price: $65

Abstract

We report on synthesis of 1,2-disubstituted benzimidazoles in pure water using nano-structured pyrophosphate Na2CaP2O7. Our findings showed that this heterogeneous catalyst exhibited high catalytic activity and high selectivity in the synthesis of 1,2- disubstituted benzimidazoles from direct cyclocondensation of aromatic aldehydes with substituted benzene-1,2-diamine in pure water. The salient benefits of this method rely on various factors namely: a simple procedure, mildness of the reaction conditions, short reaction times, operational simplicity, high chemoselectivity, low cost and recyclability of the catalyst.

Keywords: Green chemistry, heterogeneous catalysis, benzimidazoles, diaminoarene, aldehydes, recyclable catalyst.

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