摘要
背景:先天性免疫系统的病理激活可能有助于心脏代谢疾病的发展。作为先天免疫信号传导的主要转录因子的干扰素调节因子(IRF)家族成员涉及心脏代谢疾病。 目的:本综述的目的是总结当前对先天免疫反应和免疫细胞发育中IRF生物学功能的了解,并突出我们对代谢疾病,心血管重塑和中风中IRF的功能和分子机制的理解。 结果:IRF是通过免疫依赖和独立的方式进行心脏代谢疾病的基本调节剂。 结论:IRFs信号传导是治疗心脏代谢紊乱发生和进展的有希望的目标。
关键词: 干扰素调节因子信号传导,代谢疾病,心脏重塑,血管损伤,中风,血管重塑。
图形摘要
Current Drug Targets
Title:Targeting Interferon Regulatory Factor for Cardiometabolic Diseases: Opportunities and Challenges
Volume: 18 Issue: 15
关键词: 干扰素调节因子信号传导,代谢疾病,心脏重塑,血管损伤,中风,血管重塑。
摘要: Background: The pathological activation of innate immune system may contribute to the development of cardiometabolic diseases. The interferon regulatory factor (IRF) family members, which are the major transcription factors in innate immune signaling, are implicated in cardiometabolic diseases.
Objective: The aim of this review is to summary the current knowledge of the biological functions of IRFs in innate immune responses and immune cell development, and highlight our contemporary understanding of the functions and molecular mechanisms of IRFs in metabolic diseases, cardiovascular remodeling, and stroke.
Results: IRFs are the essential regulators of cardiometabolic diseases via immune-dependent and - independent manners.
Conclusion: IRFs signaling is the promising target to manage the initiation and progression of cardiometabolic disorders.
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Cite this article as:
Targeting Interferon Regulatory Factor for Cardiometabolic Diseases: Opportunities and Challenges, Current Drug Targets 2017; 18 (15) . https://dx.doi.org/10.2174/1389450116666150804110412
DOI https://dx.doi.org/10.2174/1389450116666150804110412 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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