摘要
由于潜在的健康益处和人们一般认为天然产品是安全的,普通人群包括孕妇在内,通过黄酮类食品补充剂来补充它们的饮食有增加的趋势。此外,旨在防止有毒物质,感染、遗传疾病对胎儿发育不利影响的临床前研究,其给药的类黄酮剂量远高于正常的饮食。因为这些物质未经历经典的风险评估过程,我们的目的是综述现有文献提及的孕妇的饮食补充类黄酮食品对胎儿发育的副作用。通过三个数据库进行系统的文献检索,利用四个排除标准对其进行筛选。将被选择的研究被分为两组:1。研究单类黄酮的体外毒性或动物体内毒性,和2。研究在单类黄酮或者混合黄酮类在人类身上的毒性。收集的数据表明,在人类暴露在黄酮类化合物的现实的场景中有一个问题值得担心:这些化合物在开发期间伴随着安全研究的极度缺乏,所以无法定义其安全性,除了生存的研究,尤其是更具体的发育过程等如神经系统发育更需实验阐明。在发展新的高剂量类黄酮类治疗策略用于孕妇之前,进一步研究这些化合物对孕妇安全显然是必要的。
关键词: 副作用
图形摘要
Current Drug Targets
Title:Is Intake of Flavonoid-Based Food Supplements During Pregnancy Safe for the Developing Child? A Literature Review
Volume: 18 Issue: 2
关键词: 副作用
摘要: Due to potential health benefits and the general assumption that natural products are safe, there is an increasing trend in the general population – including pregnant women – to supplement their diet with flavonoid-based food supplements. In addition, preclinical studies aim to prevent developmental adverse effects induced by toxic substances, infections, maternal or genetic diseases of the unborn child by administration of flavonoids at doses far above those reached by normal diets. Because these substances do not undergo classical risk assessment processes, our aim was to review the available literature on the potential adverse effects of maternal diet supplementation with flavonoid-based products for the developing child. A systematic literature search was performed in three databases and screened following four exclusion criteria. Selected studies were classified into two groups: 1. Studies on the developmental toxicity of single flavonoids in vitro or in animals in vivo, and 2. Studies on the developmental toxicity of single flavonoids or on flavonoid-mixtures in humans. The data collected indicate that there is a concern for the safety of some flavonoids within realistic human exposure scenarios. This concern is accompanied by a tremendous lack of studies on safety of these compounds during development making definite safety decisions impossible. Besides studies of survival, especially the more specific developmental processes like nervous system development need to be addressed experimentally. Before new high-dose, flavonoid-based therapeutic strategies are developed for pregnant women further research on the safety of these compounds is clearly needed.
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Is Intake of Flavonoid-Based Food Supplements During Pregnancy Safe for the Developing Child? A Literature Review, Current Drug Targets 2017; 18 (2) . https://dx.doi.org/10.2174/1389450116666150804110049
DOI https://dx.doi.org/10.2174/1389450116666150804110049 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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