Abstract
Tubercidin represents one of the most widely recognized nucleosides isolated from natural sources. The major structural difference between adenosine and tubercidin is that one of the nitrogen atom is replaced by a C-H group in the heterocyclic base. Tubercidin was first introduced into the clinic over 40 years ago. Since then, there has been a steady interest and this review discusses the various approaches related to the synthesis of tubercidin and its derivatives. The key aspects related to isolation, structure-activity relationships and biological activity are also discussed.
Keywords: Tubercidin, natural product, nucleosides, antibiotic, synthesis.
Graphical Abstract
Current Organic Chemistry
Title:Tubercidin and Related Analogues: An Inspiration for 50 years in Drug Discovery
Volume: 20 Issue: 8
Author(s): Varughese A. Mulamoottil
Affiliation:
Keywords: Tubercidin, natural product, nucleosides, antibiotic, synthesis.
Abstract: Tubercidin represents one of the most widely recognized nucleosides isolated from natural sources. The major structural difference between adenosine and tubercidin is that one of the nitrogen atom is replaced by a C-H group in the heterocyclic base. Tubercidin was first introduced into the clinic over 40 years ago. Since then, there has been a steady interest and this review discusses the various approaches related to the synthesis of tubercidin and its derivatives. The key aspects related to isolation, structure-activity relationships and biological activity are also discussed.
Export Options
About this article
Cite this article as:
A. Mulamoottil Varughese, Tubercidin and Related Analogues: An Inspiration for 50 years in Drug Discovery, Current Organic Chemistry 2016; 20 (8) . https://dx.doi.org/10.2174/1385272819666150803231652
DOI https://dx.doi.org/10.2174/1385272819666150803231652 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Preterm Infant Swallowing and Respiration Coordination During Oral Feeding: Relationship to Dysphagia and Aspiration
Current Pediatric Reviews Cytotoxicity and Anti-Inflammatory Effects of Polyherbal Formulations, Joint Pain Spl and Rumalaya Forte on Lipopolysaccharide Induced Inflammation in IC-21 Macrophages
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry TNF-α Polymorphisms and Maternal Depression in a Mexican Mestizo Population
CNS & Neurological Disorders - Drug Targets Approaches of the Transcriptomic Analysis in Astrocytes: Potential Pharmacological Targets
Current Pharmaceutical Design Design and Synthesis of Tetrahydroisoquinoline Derivatives as Anti-Angiogenesis and Anti-Cancer Agents
Anti-Cancer Agents in Medicinal Chemistry Brain Hyperthermia During Physiological and Pathological Conditions: Causes, Mechanisms, and Functional Implications
Current Neurovascular Research New Challenges in CNS Repair: The Immune and Nervous Connection
Current Immunology Reviews (Discontinued) Structure and Functions of the Gut Microbiome
Endocrine, Metabolic & Immune Disorders - Drug Targets An Update on JAK Inhibitors
Current Medicinal Chemistry Molecular Probes for Malignant Melanoma Imaging
Current Pharmaceutical Biotechnology Phytochemicals as Prototypes for Pharmaceutical Leads Towards Drug Development Against Diabetic Cardiomyopathy
Current Pharmaceutical Design Deregulation of the Akt Pathway in Human Cancer
Current Cancer Drug Targets The Physio-Pharmacological Role of the NPS/NPSR System in Psychiatric Disorders: A Translational Overview
Current Protein & Peptide Science Homology Modeling of Human Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 2: Insights into Isoenzyme-Specific Differences Using Molecular Docking Simulatons
Letters in Drug Design & Discovery Synthesis, Characterization and Evaluation of pH-sensitive Polyacrylamide- g-acacia Gum Microspheres for Colon Targeted Drug Delivery Application
Drug Delivery Letters CCR1 and CCR2 Antagonists
Current Topics in Medicinal Chemistry Protective Effect of Heat Shock Proteins in the Nervous System
Current Neurovascular Research Neuroprotective Methodologies in the Treatment of Multiple Sclerosis Current Status of Clinical and Pre-clinical Findings
Current Drug Discovery Technologies Mitochondrial Deficits Accompany Cognitive Decline Following Single Bilateral Intracerebroventricular Streptozotocin
Current Alzheimer Research Stage-Dependent Agreement between Cerebrospinal Fluid Proteins and FDG-PET Findings in Alzheimer's Disease
Current Alzheimer Research