摘要
葡萄膜炎是以眼内炎症为特征的疾病,不经治疗可导致视力丧失。长期控制炎症,并对全身及局部产生最小的副作用,是用于葡萄膜炎患者治疗的首选方案。葡萄膜炎的治疗药物主要是糖皮质激素的各种制剂,如外用、局部、眼内和全身制剂等。然而,由于糖皮质激素对各器官和系统产生严重不良反应,故单用效果不佳。使用类固醇类全身免疫抑制剂存在限制性,因为此类药物可能产生严重的不良反应和狭窄的治疗时窗。因此,在炎症通道各阶段起作用的较新的分子靶点似乎有望为治疗葡萄膜炎提供新策略。开发特别设计的单克隆抗体可以潜在地阻止导致疾病缓解的炎症过程。对临床前和临床研究的疗效及安全性数据进行总结,数据显示,新的分子药物及生物疗法具有可观的前景。此外,可保证高眼压治疗水平的新型给药系统已凸显端倪。
关键词: 给药系统,免疫调节疗法,非感染性的,治疗,葡萄膜炎。
Current Molecular Medicine
Title:Therapies in Development for Non-Infectious Uveitis
Volume: 15 Issue: 6
Author(s): M.A. Sadiq, A. Agarwal, M. Hassan, R. Afridi, S. Sarwar, M.K. Soliman, D.V. Do and Q.D. Nguyen
Affiliation:
关键词: 给药系统,免疫调节疗法,非感染性的,治疗,葡萄膜炎。
摘要: Uveitis represents a spectrum of diseases characterized by ocular inflammation that leads to significant visual loss if left untreated. Adequate, long-term control of inflammation with minimal systemic and local adverse effects is the preferred strategy for treating patients with uveitis. Pharmacotherapy for uveitis consists mainly of corticosteroids in various formulations such as topical, local, intraocular and systemic. However, monotherapy with corticosteroids is often unacceptable due to serious adverse effects on various organ systems. There exist limitations with the use of steroid-sparing systemic immunosuppressive agents, as these medications may have significant adverse events and a narrow therapeutic window. Thus, newer molecular targets that act on various steps of the inflammatory pathway appear to be promising emerging strategies for treating uveitis. Specially designed monoclonal antibodies in development can potentially halt the inflammatory processes resulting in remission of the disease. In the index review, novel molecular agents and biological therapies that have shown promising efficacy and safety data in preclinical and clinical studies have been summarized. In addition, new drug delivery systems that may ensure high intraocular therapeutic levels of pharmacologic agents have been highlighted.
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Cite this article as:
M.A. Sadiq, A. Agarwal, M. Hassan, R. Afridi, S. Sarwar, M.K. Soliman, D.V. Do and Q.D. Nguyen , Therapies in Development for Non-Infectious Uveitis, Current Molecular Medicine 2015; 15 (6) . https://dx.doi.org/10.2174/1566524015666150731103847
DOI https://dx.doi.org/10.2174/1566524015666150731103847 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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