αA-晶状体在实验性自身免疫性葡萄膜炎中的作用

Title:The Role of αA-Crystallin in Experimental Autoimmune Uveitis

Volume: 15 Issue: 6

Author(s): L. Wang, L. Zhang, Z.-F. Wang, Z.-X. Huang, X. Hu, L. Gong, X. Tang, F. Liu, Z. Luo and W. Ji, W.-F. Hu, Z. Woodward, J. Zhu, Y.-Z. Liu, Q.D. Nguyen and D.W.-C. Li

Affiliation:

关键词: αA晶状，实验性自身免疫性葡萄膜炎，基因治疗，葡萄膜炎。

摘要: Uveitis refers to a group of ocular inflammatory diseases that can lead to blindness. For years, researchers have been trying to decipher the underlying mechanisms and develop therapeutic strategies using the model of experimental autoimmune uveitis (EAU). Recently, αA-crystallin has been found to be upregulated in EAU and can even ameliorate its severity through different mechanisms, suggesting its use as a potent therapeutic factor against uveitis. Here we review the protective role of αA-crystallin and discuss its functional mechanisms in EAU.

Cite this article as:

L. Wang, L. Zhang, Z.-F. Wang, Z.-X. Huang, X. Hu, L. Gong, X. Tang, F. Liu, Z. Luo and W. Ji, W.-F. Hu, Z. Woodward, J. Zhu, Y.-Z. Liu, Q.D. Nguyen and D.W.-C. Li , The Role of αA-Crystallin in Experimental Autoimmune Uveitis, Current Molecular Medicine 2015; 15 (6) . https://dx.doi.org/10.2174/1566524015666150731101146