摘要
实验性自身免疫性葡萄膜炎(EAU)的小鼠模型用于模拟人类葡萄膜炎的独特功能,并作为临床前研究的模板。 “经典”EAU模型由小鼠视网膜IRBP蛋白主动免疫诱导产生,并已被证明为研究人类葡萄膜炎的基本机制和新疗法的有用工具。由IRBP靶向自身反应性T细胞诱导的几个自发性葡萄膜炎模型,最近已被开发为IRBP特异性TCR转基因小鼠(R161H)和AIRE-/-小鼠模型。“经典”免疫诱导EAU产生两种不同模式的急性眼部炎症:(i)与视网膜的广泛破坏和视功能的快速丧失相关的单相形式(ii)急性发作后期跟随的长期慢性疾病的低等形式。葡萄膜炎R161H和AIRE-/-小鼠的自发模型逐渐发作并发展为慢性眼部炎症,最终导致视网膜变性,并伴随着视频信号逐渐下降。佐剂依赖性模型和佐剂非依赖性自发模型代表人类葡萄膜炎的各种不同方面或形式。本文将讨论和比较不同葡萄膜炎模型的临床表现,病理变化,及视网膜的视觉功能,采用如眼底影像和组织学,光学相干断层成像(OCT)、视网膜电图(ERG)进行测量。
关键词: 实验性自身免疫性葡萄膜炎,视网膜电图,组织学,小鼠,光学相干断层扫描,葡萄膜炎。
Current Molecular Medicine
Title:Mouse Models of Experimental Autoimmune Uveitis: Comparative Analysis of Adjuvant-Induced vs Spontaneous Models of Uveitis
Volume: 15 Issue: 6
Author(s): J. Chen, H. Qian, R. Horai, C.-C. Chan and R.R. Caspi
Affiliation:
关键词: 实验性自身免疫性葡萄膜炎,视网膜电图,组织学,小鼠,光学相干断层扫描,葡萄膜炎。
摘要: Mouse models of experimental autoimmune uveitis (EAU) mimic unique features of human uveitis, and serve as a template for preclinical study. The “classical” EAU model is induced by active immunization of mice with the retinal protein IRBP in adjuvant, and has proved to be a useful tool to study basic mechanisms and novel therapy in human uveitis. Several spontaneous models of uveitis induced by autoreactive T cells targeting on IRBP have been recently developed in IRBP specific TCR transgenic mice (R161H) and in AIRE-/- mice. The “classical” immunizationinduced EAU exhibits acute ocular inflammation with two distinct patterns: (i) severe monophasic form with extensive destruction of the retina and rapid loss of visual function, and (ii) lower grade form with an acute onset followed by a prolonged chronic phase of disease. The spontaneous models of uveitis in R161H and AIRE-/- mice have a gradual onset and develop chronic ocular inflammation that ultimately leads to retinal degeneration, along with a progressive decline of visual signal. The adjuvant-dependent model and adjuvantfree spontaneous models represent distinct aspects and/or various forms of human uveitis. This review will discuss and compare clinical manifestations, pathology as well as visual function of the retina in the different models of uveitis, as measured by fundus imaging and histology, optical coherence tomography (OCT) and electroretinography (ERG).
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J. Chen, H. Qian, R. Horai, C.-C. Chan and R.R. Caspi , Mouse Models of Experimental Autoimmune Uveitis: Comparative Analysis of Adjuvant-Induced vs Spontaneous Models of Uveitis, Current Molecular Medicine 2015; 15 (6) . https://dx.doi.org/10.2174/1566524015666150731100318
DOI https://dx.doi.org/10.2174/1566524015666150731100318 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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