Combinatorial Synthesis of Biheterocyclic Benzimidazoles by Microwave Irradiation

Wen-Bing      Yeh; Mei-Jung      Lin; Chung-Ming      Sun

doi:10.2174/1386207043328878

Abstract

Liquid phasel synthesis of biheterocyclic benzimidazoles by controlled microwave irradiation was investigated. Polymer immobilized o-phenylenediamines was synthesized under microwave irradiation. The resulting PEG bound diamines was N-acylated with 4-fluoro-3-nitrobenzoic acid selectively in primary aromatic amino moiety. Nucleophilic aromatic substitution of amide was performed with various amines then cyclized to form the first benzimidazole scaffold in acidic condition. Successive reduction, cyclization with isothiocyanates yielded 5-(benzimidazol-2-yl)benzimidazoles. The desired products were released from the polymer support to afford the tri-substituted bis-benzimidazoles in good yields and purity.

Keywords: microwave irradiation, biheterocyclic benzimidazole, combinatorial synthesis

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