Abstract
Bischler-Napieralski (B-N) reaction is undoubtedly one of the most powerful methodologies in organic synthesis for the construction of isoquinoline moieties as important heterocyclic compounds. It has also captured great attention in the total synthesis of naturally occurring compounds such as alkaloids, which mostly and particularly bear isoquinolines as scaffold in their structures. The present review is focused on and highlighted the applications of B-N reaction, a rather old reaction, as a decisive and important stage in the total synthesis of some naturally occurring compounds including alkaloids showing significant biological activities.
Keywords: Bischler-Napieralski reaction, isoquinoline, natural product, alkaloids, total synthesis.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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