线粒体中糖尿病并发症新靶点的开发

Title:Tapping into Mitochondria to Find Novel Targets for Diabetes Complications

Volume: 17 Issue: 12

Author(s): Nicole B. Flemming, Linda A. Gallo, Micheal S. Ward, Josephine M. Forbes

Affiliation:

关键词: 糖尿病并发症，线粒体，肾病，网络工作，氧化磷酸化，视网膜病变，活性氧簇，超氧化物歧化酶

摘要: Mitochondria produce the majority of cellular energy via the “slow burn” of substrates such as glucose, free fatty acids and ketones. In diabetes, altered mitochondrial energetics and substrate utilisation may explain, in part, an organ’s susceptibility to complications. This is particularly evident at sites such as the kidney, heart, neurons and retina, which have high energy demands and oxygen consumption rates to meet functional requirements. Within this review we highlight the recent research implicating mitochondrial dysfunction, with particular focus on the contribution of mitochondrial reactive oxygen species, on the development and progression of diabetes complications. Finally, we discuss the current strategies which are being assessed to combat mitochondrial dysfunction in diabetes complications.

Cite this article as:

Nicole B. Flemming, Linda A. Gallo, Micheal S. Ward, Josephine M. Forbes , Tapping into Mitochondria to Find Novel Targets for Diabetes Complications, Current Drug Targets 2016; 17 (12) . https://dx.doi.org/10.2174/1389450116666150727114410