Abstract
Macrolide antibiotics appear to play a role in the management of diseases of chronic airway inflammation, distinctly separate from their antibactericidal activity. In the last fifteen years, their success in human clinical trials has prompted both in-vitro and in-vivo investigations to determine the mechanisms by which this family of antibiotics modulate the immune response. A large body of evidence suggests that macrolides directly target multiple components of the inflammatory cascade that occur independent of bactericidal / bacteriostatic effects. We will review the existing data in support of immunomodulatory effects of macrolides on activated leukocytes at the site of lung inflammation, on pulmonary host cells, and in animal models of lung disease.
Keywords: lung inflammation, macrolides, cytokines, leukocytes, immune response
Current Pharmaceutical Design
Title: Immunomodulatory Effects of Macrolides in the Lung: Lessons from In- Vitro and In-Vivo Models
Volume: 10 Issue: 25
Author(s): Wan C. Tsai and Theodore J. Standiford
Affiliation:
Keywords: lung inflammation, macrolides, cytokines, leukocytes, immune response
Abstract: Macrolide antibiotics appear to play a role in the management of diseases of chronic airway inflammation, distinctly separate from their antibactericidal activity. In the last fifteen years, their success in human clinical trials has prompted both in-vitro and in-vivo investigations to determine the mechanisms by which this family of antibiotics modulate the immune response. A large body of evidence suggests that macrolides directly target multiple components of the inflammatory cascade that occur independent of bactericidal / bacteriostatic effects. We will review the existing data in support of immunomodulatory effects of macrolides on activated leukocytes at the site of lung inflammation, on pulmonary host cells, and in animal models of lung disease.
Export Options
About this article
Cite this article as:
Tsai C. Wan and Standiford J. Theodore, Immunomodulatory Effects of Macrolides in the Lung: Lessons from In- Vitro and In-Vivo Models, Current Pharmaceutical Design 2004; 10 (25) . https://dx.doi.org/10.2174/1381612043383430
DOI https://dx.doi.org/10.2174/1381612043383430 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
VirDB: Crowdsourced Database for Evaluation of Dynamical Viral Infection Models
Current Bioinformatics Inhibition of Key Fungal (02) Protein(s) (Aspergillus fumigatus) In-Response to Treatment with Poly-Acid Ligand
Current Proteomics Safety of Drug Eluting Stents: Current Concerns and Controversies
Current Drug Safety Diabetes Mellitus: Channeling Care through Cellular Discovery
Current Neurovascular Research Targeting Protein Kinase C (PKC) in Physiology and Cancer of the Gastric Cell System
Current Medicinal Chemistry Antiplatelet Treatment in Peripheral Arterial Disease: The Role of Novel Antiplatelet Agents
Current Pharmaceutical Design Liver Injury Associated with Antidepressants
Current Drug Safety P-glycoprotein Inhibition: The Past, the Present and the Future
Current Drug Metabolism Possible Roles of Reg Family Proteins in Pancreatic Islet Cell Growth
Endocrine, Metabolic & Immune Disorders - Drug Targets Acne Vulgaris: an Inflammatory Disease Even Before the Onset of Clinical Lesions
Inflammation & Allergy - Drug Targets (Discontinued) Effects of Dietary L-arginine Supplementation from Conception to Post- Weaning in Piglets
Current Protein & Peptide Science Resistance Mutations Against HCV Protease Inhibitors and Antiviral Drug Design
Current Pharmaceutical Design Genetic Insights into Sporadic Parkinson's Disease Pathogenesis
Current Genomics Structure and Function of Water Molecules Buried in the Protein Core
Current Protein & Peptide Science PPARα/HNF4α Interplay on Diversified Responsive Elements. Relevance in the Regulation of Liver Peroxisomal Fatty Acid Catabolism
Current Drug Metabolism Marine Peptides and Related Compounds in Clinical Trial+
Anti-Cancer Agents in Medicinal Chemistry Cytokine, Chemokine, and Costimulatory Molecule Modulation to Enhance Efficacy of HIV Vaccines
Current Molecular Medicine Uncovering New Pharmacological Targets to Treat Neuropathic Pain by Understanding How the Organism Reacts to Nerve Injury
Current Pharmaceutical Design Costimulation, Coinhibition and Cancer
Current Cancer Drug Targets Hepatocyte Growth Factor Signaling in Cancer Metastasis
Current Signal Transduction Therapy