利用叠氮-炔点击反应合成卟啉、氯和酞菁衍生物

Title:Synthesis of Porphyrin, Chlorin and Phthalocyanine Derivatives by Azide-Alkyne Click Chemistry

Volume: 22 Issue: 28

Author(s): Samir Acherar, Ludovic Colombeau, Celine Frochot and Regis Vanderesse

Affiliation:

关键词: 点击化学， Huisgen环加成反应，光动力疗法，光敏剂，疗效。

摘要: The aim of this review is to provide a summary of the use of copper-catalyzed azide-alkyne cycloaddition (CuAAC) in the synthesis of porphyrin, chlorin and phthalocyanine derivatives for different types of therapeutic applications. The click reaction is a powerful and versatile tool for scientists working on the synthesis of various symmetrically and asymmetrically substituted tetrapyrrolic derivatives. For example, click chemistry is widely used for the elaboration of photosensitizer conjugates for photodynamic therapy applications. Other biological applications are also described.

Cite this article as:

Samir Acherar, Ludovic Colombeau, Celine Frochot and Regis Vanderesse , Synthesis of Porphyrin, Chlorin and Phthalocyanine Derivatives by Azide-Alkyne Click Chemistry, Current Medicinal Chemistry 2015; 22 (28) . https://dx.doi.org/10.2174/0929867322666150716115832