摘要
背景:采用不同类型的脑激活,可以通过功能性磁共振成像(fMRI)准确地研究认知和运动性能,尤其是在老年受试者。血管危险因素(VRFs)是认知功能障碍的发展中及其发展,但很少有研究关注的功能磁共振成像大脑皮质的激活特性的健康受试者与无症状脑血管疾病包括白质高信号(WMH)与颈动脉狭窄(CS)执行认知任务。方法:305名无症状的单侧颈动脉狭窄70%以上,WMH变量度是进行一个简单的运动和认知任务的功能磁共振成像期间表现。结果:然而在皮层激活依赖的年龄,但不是WMH和颈动脉狭窄导致的电机任务的性能,认知任务的性能是伴随着显着增加激活独立相关和伴随着年龄的增长,WMH以及颈动脉狭窄存在的。结论:在这项研究中,认知域调节注意力和工作记忆似乎受颈动脉狭窄和白质高信号激活这一种模式影响。这些认知能力的障碍与阿尔茨海默氏症病理的相关性很高。fMRI模式所示患者无症状,但明显颈动脉狭窄存在一个重要的病理生理机制,就是可能与慢性脑缺血相关。在这些患者中,颈动脉内膜剥脱术应该被认为是AD预防和可能,从而得到推荐。
关键词: 认知障碍,自然老化,动脉内膜中层厚度,血管病变,维生素。
Current Alzheimer Research
Title:Differential Influence of Carotid Stenosis and White Matter Disease on Motor and Cognitive Activation
Volume: 12 Issue: 6
Author(s): M. C. Polidori, V. Calistri, C. Mainero, E. Tinelli, A. Aceti, M. Pontico, S. Tardioli, M. Santini, M. Fiorelli, M. A. Panico and F Speziale, M. D. Caramia, R. -J. Schulz and F. Caramia
Affiliation:
关键词: 认知障碍,自然老化,动脉内膜中层厚度,血管病变,维生素。
摘要: Background: Cognitive and motor performance can be supported, especially in older subjects, by different types of brain activations, which can be accurately studied by functional magnetic resonance imaging (fMRI). Vascular risk factors (VRFs) are extremely important in the development of cognitive impairment, but few studies have focused on the fMRI cortical activation characteristics of healthy subjects with and without silent cerebrovascular disease including white matter hyperintensities (WMH) and carotid stenosis (CS) performing cognitive tasks. Methods: Thirty-five volunteers with and without asymptomatic unilateral carotid stenosis above 70% and variable degrees of WMH underwent performance of a simple motor and cognitive task during an fMRI session. Results: While the performance of the motor task resulted in a cortical activation dependent of age but not of WMH and carotid stenosis, performance of the cognitive task was accompanied by a significantly increased activation independently correlated with age, presence of WMH as well as of carotid stenosis. Conclusions: in this study, cognitive domains regulating attention and working memory appear to be activated with a pattern influenced by the presence of carotid stenosis as well as by white matter hyperintensities. The impairment of these cognitive abilities is of high relevance in Alzheimer’s disease pathology. The fMRI pattern shown in patients with asymptomatic but significant carotid stenosis might be related to chronic cerebrovascular hypoperfusion, a critical pathophysiological mechanisms in AD. In these patients, carotid endoarterectomy should be considered also for AD prevention and might be recommended.
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M. C. Polidori, V. Calistri, C. Mainero, E. Tinelli, A. Aceti, M. Pontico, S. Tardioli, M. Santini, M. Fiorelli, M. A. Panico and F Speziale, M. D. Caramia, R. -J. Schulz and F. Caramia , Differential Influence of Carotid Stenosis and White Matter Disease on Motor and Cognitive Activation, Current Alzheimer Research 2015; 12 (6) . https://dx.doi.org/10.2174/156720501206150716115514
DOI https://dx.doi.org/10.2174/156720501206150716115514 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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