摘要
脂蛋白相关的或载脂蛋白有针对性的纳米粒子作为药物载体的集成纳米开辟了新的治疗和诊断的途径。这个概念是利用脂蛋白颗粒的固有特 性作为非极性脂质的天然转运和脂肪在人体循环。离散脂蛋白组件和脂蛋白为基础的仿生提供了一个多功能的纳米颗粒平台,它可以被操纵 ,并调整为特定的医疗用途。本文叙述了构建装载药物,重组或人工脂蛋白颗粒的可能性。输送系统的优点和局限性审慎评估和未来潜在的 挑战,特别是关于目标的特殊性,概念脂蛋白重路由,并使用载脂蛋白序列作为靶向部分论述创新脂蛋白模拟颗粒设计。最后,该文综述 了靶向注重从文献的例子强调潜在的医学应用脂蛋白基于纳米颗粒体系在心血管研究,癌症治疗,基因传递和大脑的领域。
关键词: 载脂蛋白,人造脂蛋白,高密度脂蛋白,脂蛋白相关纳米粒子,低密度脂蛋白,重组脂蛋白,重组脂蛋白,人造脂蛋白
Current Medicinal Chemistry
Title:Lipoprotein-Related and Apolipoprotein-Mediated Delivery Systems for Drug Targeting and Imaging
Volume: 22 Issue: 31
Author(s): Gunter Almer, Harald Mangge, Andreas Zimmer and Ruth Prassl
Affiliation:
关键词: 载脂蛋白,人造脂蛋白,高密度脂蛋白,脂蛋白相关纳米粒子,低密度脂蛋白,重组脂蛋白,重组脂蛋白,人造脂蛋白
摘要: The integration of lipoprotein-related or apolipoprotein-targeted nanoparticles as pharmaceutical carriers opens new therapeutic and diagnostic avenues in nanomedicine. The concept is to exploit the intrinsic characteristics of lipoprotein particles as being the natural transporter of apolar lipids and fat in human circulation. Discrete lipoprotein assemblies and lipoprotein-based biomimetics offer a versatile nanoparticle platform that can be manipulated and tuned for specific medical applications. This article reviews the possibilities for constructing drug loaded, reconstituted or artificial lipoprotein particles. The advantages and limitations of lipoproteinbased delivery systems are critically evaluated and potential future challenges, especially concerning targeting specificity, concepts for lipoprotein rerouting and design of innovative lipoprotein mimetic particles using apolipoprotein sequences as targeting moieties are discussed. Finally, the review highlights potential medical applications for lipoprotein-based nanoparticle systems in the fields of cardiovascular research, cancer therapy, gene delivery and brain targeting focusing on representative examples from literature.
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Cite this article as:
Gunter Almer, Harald Mangge, Andreas Zimmer and Ruth Prassl , Lipoprotein-Related and Apolipoprotein-Mediated Delivery Systems for Drug Targeting and Imaging, Current Medicinal Chemistry 2015; 22 (31) . https://dx.doi.org/10.2174/0929867322666150716114625
DOI https://dx.doi.org/10.2174/0929867322666150716114625 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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