摘要
老年痴呆症对全球健康来说是一个巨大的挑战,因为随着人口老龄化,老年痴呆症会增加社会的负担。鉴于对常见类型的老年痴呆症,包括阿尔茨海默氏病和血管性痴呆,缺乏有效的药物治疗,因而,对于可以防止、推迟老年痴呆临床综合征或减慢老年痴呆发展进程的生活方式的研究也日益增加。在测试不同的饮食习惯对认知的影响时发现传统的地中海饮食(MeDi)有着出可喜的结果。本文旨在总结地中海饮食(MeDi)对老年痴呆症预防作用的流行病学证据,本文数据来自在对地中海和非地中海国家的横向和纵向研究。这些研究结果也已在最近的一项随机对照临床试验中得到再现。本文也简单的讨论了地中海饮食对认知功能障碍的潜在保护作用的假设机制。尽管地中海饮食和认知能力下降之间的联系只被研究了不到十年的时间,然而正在迅速增加的有效数据表明地中海饮食可能成为老年痴呆症的另一种预防性治疗措施。
关键词: 阿尔茨海默病、认知减退、痴呆、地中海饮食、初级预防、公共卫生。
Current Alzheimer Research
Title:Mediterranean Diet and Risk of Dementia
Volume: 12 Issue: 8
Author(s): Apostolos Safouris, Georgios Tsivgoulis, Theodoros N. Sergentanis and Theodora Psaltopoulou
Affiliation:
关键词: 阿尔茨海默病、认知减退、痴呆、地中海饮食、初级预防、公共卫生。
摘要: Dementia is a major global health challenge, as its burden on society will increase with population aging. Given the lack of effective pharmaceutical treatment for common types of dementia including Alzheimer’s disease and vascular dementia, research interest in lifestyle modifications that could prevent, postpone the clinical syndrome or decelerate progression of dementia is growing. Among the various dietary patterns that were tested for their effects on cognition, the traditional Mediterranean diet (MeDi) has shown promising results. This review aims to summarize the epidemiological evidence on the effects of MeDi on the prevention of dementia, presenting data from cross-sectional as well as longitudinal observational studies conducted both in Mediterranean and non-Mediterranean countries. These findings have been also reproduced in the context of one recent randomizedcontrolled clinical trial. Postulated mechanisms of action that may account for the potential protective effect of MeDi on cognitive impairment will be briefly discussed. Despite the fact that the link between MeDi and cognitive decline has been only explored for less than a decade, data on efficacy is rapidly increasing and allows optimism that MeDi could emerge as an alternative prophylactic treatment for dementia.
Export Options
About this article
Cite this article as:
Safouris Apostolos, Tsivgoulis Georgios, Sergentanis N. Theodoros and Psaltopoulou Theodora, Mediterranean Diet and Risk of Dementia, Current Alzheimer Research 2015; 12 (8) . https://dx.doi.org/10.2174/1567205012666150710114430
DOI https://dx.doi.org/10.2174/1567205012666150710114430 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Cognitive Reserve in Aging
Current Alzheimer Research The Role of Functional Neuroimaging in Mild Cognitive Impairment
Current Medical Imaging MicroRNAs in Cardiovascular Therapeutics
Current Topics in Medicinal Chemistry Preface
Current Psychopharmacology Mild Parkinsonian Signs in a Hospital-based Cohort of Mild Cognitive Impairment Types: A Cross-sectional Study
Current Alzheimer Research Vaccination to Alzheimer Disease. Is it a Promising Tool or a Blind Way?
Current Medicinal Chemistry The Gut-Brain Axis, Including the Microbiome, Leaky Gut and Bacterial Translocation: Mechanisms and Pathophysiological Role in Alzheimer’s Disease
Current Pharmaceutical Design Role of the α7 Nicotinic Acetylcholine Receptor and RIC-3 in the Cholinergic Anti-inflammatory Pathway
Central Nervous System Agents in Medicinal Chemistry Glucagon-Like Peptide-1-Mediated Modulation of Inflammatory Pathways in the Diabetic Brain: Relevance to Alzheimer’s Disease
Current Alzheimer Research The Molecular Basis of Memantine Action in Alzheimers Disease and Other Neurologic Disorders: Low-affinity, Uncompetitive Antagonism
Current Alzheimer Research Toll-Like Receptors in Alzheimer's Disease: A Therapeutic Perspective
CNS & Neurological Disorders - Drug Targets Perioperative Handling of Antiplatelet Drugs. A Critical Appraisal
Current Drug Targets The Mechanisms and Quantification of the Selective Permeability in Transport Across Biological Barriers: the Example of Kyotorphin
Mini-Reviews in Medicinal Chemistry Apolipoprotein E-mediated Modulation of ADAM10 in Alzheimer's Disease
Current Alzheimer Research Quantitative Ultrasound in Diagnosis of Metabolic Bone Diseases
Current Medical Imaging Rashes, Sniffles, and Stroke: A Role for Infection in Ischemic Stroke of Childhood
Infectious Disorders - Drug Targets The Novel Role for Lyn in Integrin Signaling in Human Disease
Current Signal Transduction Therapy Editorial (Thematic Issue: Neuroglia as a Central Element of Neurological Diseases: An Underappreciated Target for Therapeutic Intervention)
Current Neuropharmacology Possible Roles of Microglial Cells for Neurotoxicity in Clinical Neurodegenerative Diseases and Experimental Animal Models
Inflammation & Allergy - Drug Targets (Discontinued) An Insight into the Therapeutic Potential of Major Coffee Components
Current Drug Metabolism