（癌症中的缺口信号：目标的基本原理和策略）

Title:Notch Signaling in Cancer: Rationale and Strategies for Targeting

Volume: 15 Issue: 5

Author(s): Aisha Alketbi and Samir Attoub

Affiliation:

关键词: 癌症，单克隆抗体，缺口抑制，缺口信号，分泌酶抑制剂

摘要: The Notch signaling pathway is a highly conserved system that controls embryonic cell fate decisions and the maintenance of adult stem cells through affecting communication between adjacent cells. The pathway is linked to the development of various cancers owing to increased cell proliferation and tumor blood perfusion in addition to inhibition of apoptosis. Pharmaceutical agents that suppress overactive Notch signaling may be of benefit in the treatment of patients with various cancers. These targeted therapies confer several advantages over conventional anticancer therapies including reduced deleterious effects on normal cells. In this review, we explore the rationale for targeting the Notch signaling pathway in cancer along with different investigational strategies designed to block the pathway.

Cite this article as:

Aisha Alketbi and Samir Attoub , Notch Signaling in Cancer: Rationale and Strategies for Targeting, Current Cancer Drug Targets 2015; 15 (5) . https://dx.doi.org/10.2174/156800961505150710113353