摘要
背景:据报道,牙周炎与阿尔茨海默病有关。然而,虽然嗅觉障碍经常发生在老年痴呆或阿尔茨海默病之前,鼻窦炎和阿尔茨海默病之间的确切联系并没有得到研究。方法:我们研究了783例参观国家老年医学和老年康复医学中心记忆障碍综合护理中心的患者(男283例,女500例,平均年龄77± 7.9岁)以及 2139人所组成的控制组,控制组人员参加了一项由日本国家长寿科学研究所发起的一项以人群为基础的研究。按照Lund–Mackay评分体系,使用磁共振成像(MRI)对鼻窦炎进行评估。鼻窦炎评分≥ 4为阳性, ≤ 3 为阴性。结果: 简短精神状态检查(MMSE)得分< 24 (n = 507)的阳性鼻窦炎的患病率为 6.3%,而AD患者阳性鼻窦炎的患病率为5.7% 。在对照组中,阳性鼻窦炎比率为7.2%。在对年龄和性别进行调整后,鼻窦炎的患病率在正常对照组和老年痴呆症患者之间没有显著差异。两组患者中,男性鼻窦炎阳性比率均高于女性。结论:阿尔茨海默病或痴呆患者鼻窦炎的患病率不比普通人群高。
关键词: 阿尔茨海默病,老年痴呆,Lund–Mackey评分体系,磁共振成像,简易精神状态检查。
Current Alzheimer Research
Title:Prevalence of Sinusitis Detected by Magnetic Resonance Imaging in Subjects with Dementia or Alzheimer’s Disease
Volume: 12 Issue: 10
Author(s): Minori Yasue, Saiko Sugiura, Yasue Uchida, Hironao Otake, Masaaki Teranishi, Takashi Sakurai, Kenji Toba and Hiroshi Shimokata, Fujiko Ando, Rei Otsuka, Tsutomu Nakashima
Affiliation:
关键词: 阿尔茨海默病,老年痴呆,Lund–Mackey评分体系,磁共振成像,简易精神状态检查。
摘要: Background: It has been reported that periodontitis is associated with Alzheimer’s disease. However, the association between paranasal sinusitis and Alzheimer’s disease has not been studied, although olfactory dysfunction frequently precedes the progress of dementia or Alzheimer’s disease. Methods: We studied 783 patients (283 men, 500 women; mean age 77.0 ± 7.9 years) who visited the Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology, and 2139 control subjects who participated in a population-based study conducted by the National Institute for Longevity Sciences – Longitudinal Study of Aging (NILS–LSA) in Japan. Sinusitis was evaluated using magnetic resonance imaging (MRI) according to the Lund–Mackay scoring system. A sinusitis score of ≥ 4 was classified as positive and a score of ≤ 3 was classified as negative. Results: The prevalence of positive sinusitis was 6.3% in patients with a mini-mental state examination (MMSE) score of < 24 (n = 507), and 5.7% in patients with Alzheimer’s disease (n = 280). The rate of positive sinusitis was7.2% in the control group. The prevalence of sinusitis was not significantly different between normal controls and patients with dementia or Alzheimer’s disease after adjustments for age and sex. The rate of positive sinusitis was higher in male than in female subjects in both groups. Conclusion: The prevalence of sinusitis in patients with Alzheimer’s disease or dementia was not higher than in the general population.
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Minori Yasue, Saiko Sugiura, Yasue Uchida, Hironao Otake, Masaaki Teranishi, Takashi Sakurai, Kenji Toba and Hiroshi Shimokata, Fujiko Ando, Rei Otsuka, Tsutomu Nakashima , Prevalence of Sinusitis Detected by Magnetic Resonance Imaging in Subjects with Dementia or Alzheimer’s Disease, Current Alzheimer Research 2015; 12 (10) . https://dx.doi.org/10.2174/1567205012666150710105152
DOI https://dx.doi.org/10.2174/1567205012666150710105152 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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