摘要
背景:心血管疾病,特别是缺血性心脏病和心脏代谢疾病,仍然是全球发病率和死亡率的主要原因。尽管诊断和治疗方法最近取得了进展,心血管疾病的发病率仍在上升。因此,迫切需要采取替代治疗方案来挽救快速增长的患者。 目的:本文旨在回顾相关作用,探讨SIRT1作为保护心脏缺血/再灌注损伤和心脏代谢疾病的有希望的靶标的可能性。 结果:SIRT1的激活参与心脏缺血损伤和心脏代谢疾病中的各种重要的代谢和生理过程,包括抗逆性,代谢,凋亡和能量平衡。 结论:目前针对SIRT1的药物可能代表了预防与能量平衡和代谢相关的心血管疾病的新治疗趋势。
关键词: SIRT1,缺血再灌注损伤,代谢疾病,心脏,白藜芦醇,治疗,靶标
图形摘要
Current Drug Targets
Title:SIRT1 as a Promising Novel Therapeutic Target for Myocardial Ischemia Reperfusion Injury and Cardiometabolic Disease
Volume: 18 Issue: 15
关键词: SIRT1,缺血再灌注损伤,代谢疾病,心脏,白藜芦醇,治疗,靶标
摘要: Background: Cardiovascular diseases, especially ischemic heart disease and cardiometabolic disease, remain to be the leading cause of morbidity and mortality worldwide. Despite recent progress in diagnostic and therapeutic approaches, the incidence of cardiovascular disease is still rising. Therefore, alternative favorable treatment is urgently needed to rescue the fast growing numbers of patients.
Objective: Herein we aimed to review the relevant role and explore the possibility of SIRT1 as a promising target for protection of heart from ischemia/reperfusion injury and cardiometabolic diseases.
Results: The activation of SIRT1 participates in a variety of important metabolic and physiologic processes including stress resistance, metabolism, apoptosis and energy balance in heart ischemia injury and cardiometabolic disease.
Conclusion: Current medication targeting SIRT1 may represent a new therapeutic trend for the prevention of cardiovascular disease that is related to energy balance and metabolism.
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Cite this article as:
SIRT1 as a Promising Novel Therapeutic Target for Myocardial Ischemia Reperfusion Injury and Cardiometabolic Disease, Current Drug Targets 2017; 18 (15) . https://dx.doi.org/10.2174/1389450116666150630110529
DOI https://dx.doi.org/10.2174/1389450116666150630110529 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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