Abstract
Systems biology strives to derive comprehensive and accurate descriptions of complex systems such as the innate immune system. The innate immune system is essential for host defense and is responsible for early detection and containment of pathogens, yet the resulting inflammatory response is a double-edged sword that must be tightly regulated. Our current understanding indicates that the innate immune system is controlled by complex regulatory networks, which contain cross-talk, insulation, feedback loops, signal amplification, integration and dampening. Such dynamic behavior and complexity are essential to innate immunity, and critical for maintaining homoeostasis and accurately distinguishing pathogenic microbial infections from harmless threats. We focus this review on Toll-like receptor regulation of innate immune response to microbial pathogens, and emphasize recent studies using high throughput technologies and computational approaches in this field. The eventual integration of global molecular and interaction data into predictive models will provide the necessary foundation to cultivate a systems level understanding of innate immunity.
Keywords: innate immunity, toll-like receptors, systems biology, genomics, proteomics, computational biology
Current Genomics
Title: Exploring Toll-Like Receptor Regulation of Innate Immunity with the Tools of Systems Biology
Volume: 5 Issue: 7
Author(s): Kelly D. Smith and Vesteinn Thorsson
Affiliation:
Keywords: innate immunity, toll-like receptors, systems biology, genomics, proteomics, computational biology
Abstract: Systems biology strives to derive comprehensive and accurate descriptions of complex systems such as the innate immune system. The innate immune system is essential for host defense and is responsible for early detection and containment of pathogens, yet the resulting inflammatory response is a double-edged sword that must be tightly regulated. Our current understanding indicates that the innate immune system is controlled by complex regulatory networks, which contain cross-talk, insulation, feedback loops, signal amplification, integration and dampening. Such dynamic behavior and complexity are essential to innate immunity, and critical for maintaining homoeostasis and accurately distinguishing pathogenic microbial infections from harmless threats. We focus this review on Toll-like receptor regulation of innate immune response to microbial pathogens, and emphasize recent studies using high throughput technologies and computational approaches in this field. The eventual integration of global molecular and interaction data into predictive models will provide the necessary foundation to cultivate a systems level understanding of innate immunity.
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Cite this article as:
Smith D. Kelly and Thorsson Vesteinn, Exploring Toll-Like Receptor Regulation of Innate Immunity with the Tools of Systems Biology, Current Genomics 2004; 5 (7) . https://dx.doi.org/10.2174/1389202043348706
DOI https://dx.doi.org/10.2174/1389202043348706 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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