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Current Diabetes Reviews

Editor-in-Chief

ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

Review Article

Islet Compensation in Metabolic Stress: Lessons from Animal Models

Author(s): Himadri Singh

Volume 12, Issue 4, 2016

Page: [315 - 321] Pages: 7

DOI: 10.2174/1573399811666150617161915

Price: $65

Abstract

Type 2 diabetes is characterized by decreased functional beta-cell mass, as a consequence of metabolic stress associated with obesity, aging, insulin resistance and pregnancy. The metabolic stress is caused by increased insulin demand, pro-inflammatory cytokines, and free fatty acids. Fortunately, islets have remarkable property to adapt to increased metabolic demand. This review focuses on the mechanisms of islet adaptation to metabolic stress in obesity and insulin resistance

Keywords: Islets, adaptation, hypertrophy, epigenetics, beta-cells, models.


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