摘要
恶性脑肿瘤包括原发性脑肿瘤(例如,多形性胶质母细胞瘤)及转移,对于多数患者来说,其为具有侵略性和致命性的实体。目前的标准治疗方法,包括手术,放疗和全身化疗相结合的方法仅适度改善患者病情。针对这些微弱的生命,急需尽力寻找有效的治疗方案。然而,血脑屏障(BBB)和血肿瘤屏障(BTB)是药物输送至脑肿瘤部位的的障碍。为达到恶性脑肿瘤更好的治疗效果需要优化给药方式,这是得到普遍公认的。某些引起关注的给药方式,如使用外科手术或物理技术,以提高治疗药物在中枢神经系统的分布。本文将以下给药方式进行综述:动脉内给药,透过血脑屏障给药,鼻腔给药,增强对流给药和渗透泵给药,皮下植入聚合物和磁性微球,超声破坏血脑屏障给药。本文目的是综述血脑屏障(BBB)和血肿瘤屏障(BTB)的重要性,及阐述上述给药方式的现状和前景。
关键词: 血脑屏障,血脑屏障破坏,脑肿瘤,化疗,药物输送,多形性胶质母细胞瘤,靶向给药。
图形摘要
Current Cancer Drug Targets
Title:Chemotherapy Delivery Strategies to the Central Nervous System: neither Optional nor Superfluous
Volume: 15 Issue: 9
Author(s): Annie Drapeau and David Fortin
Affiliation:
关键词: 血脑屏障,血脑屏障破坏,脑肿瘤,化疗,药物输送,多形性胶质母细胞瘤,靶向给药。
摘要: Malignant brain tumors including primary brain tumors (e.g., glioblastoma multiforme) and metastases, are aggressive and lethal entities for the majority of affected patients. Current standard treatments involving combinations of surgery, radiotherapy and systemic chemotherapy offer only modest improvements in survival. Faced with dismal survival, great efforts are deployed to find interesting treatment alternatives. However, the blood-brain barrier (BBB) and the blood-tumor barrier (BTB) remain great obstacles to significant drug delivery to brain tumors. The need to optimize delivery strategies for better patient outcome in the treatment of malignant brain tumors is well acknowledged. Certain interesting strategies use surgical or physical techniques to enhance the distribution of therapeutic agents to the central nervous system. The following strategies will be discussed in this review: intra-arterial delivery, osmotic BBB disruption, intranasal delivery, convection-enhanced delivery and osmotic pumps, implanted polymers, magnetic microspheres and ultrasound BBB disruption. The purpose of this paper is to review the importance of the BBB and the BTB and to review the current status and future perspectives of these delivery procedures.
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Cite this article as:
Annie Drapeau and David Fortin , Chemotherapy Delivery Strategies to the Central Nervous System: neither Optional nor Superfluous, Current Cancer Drug Targets 2015; 15 (9) . https://dx.doi.org/10.2174/1568009615666150616123548
DOI https://dx.doi.org/10.2174/1568009615666150616123548 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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