摘要
精子的形成与雄性生殖道的各种组织中的水和管腔中电解液的运动有关。囊性纤维化跨膜传导调节因子(CFTR)是一种cAMP激活的Cl-和HCO3-膜转运蛋白。囊性纤维化跨膜传导调节因子(CFTR)是一种cAMP激活的Cl-和HCO3-膜转运蛋白。值得注意的是,CF中的一个特征即是男性不育症。的确,CFTR基因突变导致生殖细胞异常,降低生殖细胞的质量和数量。值得注意的是,在CF中的一个特征是男性不育症。的确,CFTR基因突变导致生殖细胞异常产生及生殖细胞的质量和数量的下降。CFTR参与的表现男性的生育能力的几个关键键过程,包括精子发生和精子获能。最近的研究表明,CFTR作在体睾丸细胞中为特定水通道的分子伴侣,被称为水通道蛋白。水通道蛋白是选择性水通道,使高渗透通量的水跨越质膜。在男性生殖道中,水的转运和离子浓度是男性生殖功能的决定性因素。因此,水通道蛋白的表达和功能在男性的生育能力中起着关键的作用。在此,我们概述了在男性生殖道中CFTR的表达和功能,强调了CFTR基因突变的男性携带者和CF夫妇的生殖结果。我们对男性生殖道中水通道蛋白的表达和功能进行了最新讨论。最后,我们总结了男性生殖道中通过CFTR调节水通道蛋白调节介导的水转运及其对男性生育能力的意义。
关键词: 水通道蛋白,囊性纤维化跨膜电传导调节因子(CFTR),男性生殖道,雄性可育性,精子发生
图形摘要
Current Drug Targets
Title:CFTR Regulation of Aquaporin-Mediated Water Transport: A Target in Male Fertility
Volume: 16 Issue: 9
Author(s): Marco G. Alves, Rosália Sá, Tito T. Jesus, Mário Sousa and Pedro F. Oliveira
Affiliation:
关键词: 水通道蛋白,囊性纤维化跨膜电传导调节因子(CFTR),男性生殖道,雄性可育性,精子发生
摘要: The formation of competent spermatozoa is associated with the movement of large quantities of water and electrolytes in the various tissues and luminal fluids of the male reproductive tract. The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-activated Cl− and HCO3 − membrane transporter. CFTR gene mutations cause cystic fibrosis (CF), the most common lethal genetic disease in Caucasians. Of note, one hallmark in CF is male infertility. Indeed, mutations of CFTR gene cause abnormal production of germ cells and a reduction in germ cell quality and number. Compelling evidence illustrates that CFTR is involved in several pivotal processes for male fertility, including spermatogenesis and sperm capacitation. Recent studies show that CFTR acts as a molecular partner of specific water channels, known as aquaporins, in somatic testicular cells. Aquaporins are water-selective channels that enable high permeability fluxes of water across plasma membranes. In the male reproductive tract, water movements and ion concentrations are determinants for the male reproductive function. Therefore, aquaporins expression and function play a key role in male fertility. Herein we present an overview of the expression and function of CFTR in the male reproductive tract, highlighting the reproductive outcomes in male carriers of CFTR mutations and CF couples. We also present an up-to-date discussion on the expression and role of aquaporins in the male reproductive tract. Finally, we discuss the regulation of aquaporin-mediated water transport by CFTR in the male reproductive tract and its implication for male fertility.
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Marco G. Alves, Rosália Sá, Tito T. Jesus, Mário Sousa and Pedro F. Oliveira , CFTR Regulation of Aquaporin-Mediated Water Transport: A Target in Male Fertility, Current Drug Targets 2015; 16 (9) . https://dx.doi.org/10.2174/1573399811666150615144108
DOI https://dx.doi.org/10.2174/1573399811666150615144108 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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