Abstract
Recently, DNA modifications, in vitro or in vivo, have attracted much attention because of the enhanced structural diversity and functionality of the modified DNA, and their broadened applications. In doing so, the availability of modified nucleosides/tides that can still be recognized by various enzymes required for the incorporation of nucleobases into DNA is critical. In this review, recent progress in developing such modified nucleosides/tides is summarized based on structural modification sites. Various modification strategies are compared and contrasted.
Keywords: DNA functionalization, enzymatic incorporation, fluorescent labeling, metabolic labeling, oligonucleotides, live cell imaging
Graphical Abstract
Current Organic Chemistry
Title:Modified Nucleosides That Can Be Incorporated into DNA Enzymatically or in Live Cells
Volume: 19 Issue: 11
Author(s): Ke Wang, Danzhu Wang and Binghe Wang
Affiliation:
Keywords: DNA functionalization, enzymatic incorporation, fluorescent labeling, metabolic labeling, oligonucleotides, live cell imaging
Abstract: Recently, DNA modifications, in vitro or in vivo, have attracted much attention because of the enhanced structural diversity and functionality of the modified DNA, and their broadened applications. In doing so, the availability of modified nucleosides/tides that can still be recognized by various enzymes required for the incorporation of nucleobases into DNA is critical. In this review, recent progress in developing such modified nucleosides/tides is summarized based on structural modification sites. Various modification strategies are compared and contrasted.
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Cite this article as:
Wang Ke, Wang Danzhu and Wang Binghe, Modified Nucleosides That Can Be Incorporated into DNA Enzymatically or in Live Cells, Current Organic Chemistry 2015; 19 (11) . https://dx.doi.org/10.2174/138527281911150610101141
DOI https://dx.doi.org/10.2174/138527281911150610101141 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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