Abstract
Recently, DNA modifications, in vitro or in vivo, have attracted much attention because of the enhanced structural diversity and functionality of the modified DNA, and their broadened applications. In doing so, the availability of modified nucleosides/tides that can still be recognized by various enzymes required for the incorporation of nucleobases into DNA is critical. In this review, recent progress in developing such modified nucleosides/tides is summarized based on structural modification sites. Various modification strategies are compared and contrasted.
Keywords: DNA functionalization, enzymatic incorporation, fluorescent labeling, metabolic labeling, oligonucleotides, live cell imaging
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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