Zein-Based Nanofibres for Drug Delivery: Classes and Current Applications

Title:Zein-Based Nanofibres for Drug Delivery: Classes and Current Applications

Volume: 21 Issue: 22

Author(s): Yong Zhang, Lili Cui, Yan Chen, Heng Zhang, Jian Zhong, Yanan Sun, Nianqiu Shi, Chunlei Li and Wei Kong

Affiliation:

Keywords: Biocompatibility, biomedical application, biopolymer, immunogenicity, zein.

Abstract: Plant proteins have been drawing increasing attention owing to their safety, abundance and relatively low cost in comparison with animal proteins. The development of plant protein-based delivery vehicles may lead to the provision of novel pharmaceutical products to patients. Zein is a class of alcohol-soluble prolamine proteins present in maize endosperm that was approved as a generally recognised as safe excipient in 1985 by the US FDA for use in pharmaceutical film coatings. Over the past few decades, numerous studies have been carried out to illustrate zein’s potential for novel applications in the biomedical field. This paper reviews the present status of zein-based nanofibres, with emphasis on their fabrication and biomedical applications, particularly for drug delivery. Their benefits and limitations are also discussed to provide further insight into zein’s potential as a promising biomaterial.

Cite this article as:

Zhang Yong, Cui Lili, Chen Yan, Zhang Heng, Zhong Jian, Sun Yanan, Shi Nianqiu, Li Chunlei and Kong Wei, Zein-Based Nanofibres for Drug Delivery: Classes and Current Applications, Current Pharmaceutical Design 2015; 21 (22) . https://dx.doi.org/10.2174/1381612821666150531170448