天然产物作治疗非酒精性脂肪肝

Title:Natural Products on Nonalcoholic Fatty Liver Disease

Volume: 16 Issue: 12

Author(s): Jiao-Ya Xu, Li Zhang, Zhong-Ping Li and Guang Ji

Affiliation:

关键词: 天然产物，非酒精性脂肪肝，脂肪代谢，糖代谢，炎症，内质网应激。

摘要: Non-alcoholic fatty liver disease (NAFLD) is a chronic disorder of lipid and carbohydrate metabolism and is often associated with endoplasmic reticulum stress, energy homeostasis dysregulation, and inflammation at cellular and molecular levels. Use of currently available anti-hyperlipidemia, hypoglycemia, or anti-inflammation drugs to treat NAFLD has not achieved desirable outcomes. A growing attention thus has been paid towards natural products as an alternative means in treating NALFD. Some of the natural products apparently possess the properties of ameliorating symptoms of NAFLD through restoration of lipid and carbohydrate metabolism and energy homeostasis. Data from recent animal and human studies concerning the use of natural products in the treatment of NAFLD are analyzed, and the potential underlying mechanisms are discussed.

Cite this article as:

Jiao-Ya Xu, Li Zhang, Zhong-Ping Li and Guang Ji , Natural Products on Nonalcoholic Fatty Liver Disease, Current Drug Targets 2015; 16 (12) . https://dx.doi.org/10.2174/1389450116666150531155711