摘要
背景:结构的磁共振成像(MRI)提供了关键的生物标志物来预测发病和跟踪阿尔茨海默氏病(AD)进展。然而,最多的研究报告MRI变量和中老年人认知之间的关系包括种族,民族和社会经济同等的采样。在MRI变量和认知能力的种族/族裔的差异,以及健康,社会经济状况和心理因素,提高的可能性,脑与行为的关系可能在不同的群体更强或更弱。当前的研究测试了,与非西班牙裔白人方法相比,是否MRI预测不同的非裔美国人和拉美裔美国人的认识有差异。方法:从华盛顿高地-伍德哥伦比亚老化项目收集638非痴呆老年人(29%的非西班牙裔白人,36%的非裔美国人,35%西班牙裔美国人)。来源于成套的神经心理学测试,包括记忆,语言,速度/执行功能,视觉空间功能的得分进行综合。FreeSurfer和内部开发的程序对海马体积、区域皮质厚度、梗塞和白质高信号(WMH)卷进行量化。多组回归分析,其中每个认知综合得分被回归到MRI变量,人口统计和心血管健康,测试不同组中哪些通路存在差异。结果:较大的WMH的卷积与非洲裔美国更糟的语言和速度/执行功能相关,但在非西班牙裔白人中不相关。西班牙人非西班牙裔白人相比,较大海马体积与更好的记忆成强有关。皮质厚度和梗塞认知关系在各个组间相似。结论。这项研究的主要发现是某些MRI认知预测在不同种族/族裔群体是不同。这些结果强调在认知老化的研究中需要更多样化的样本,因为类型和认知功能的神经生物学基础之间关系可能在不同的组群是不同的。
关键词: 老化,认知,种族,核磁共振。
Current Alzheimer Research
Title:Structural MRI Predictors of Late-Life Cognition Differ Across African Americans, Hispanics, and Whites
Volume: 12 Issue: 7
Author(s): Laura B. Zahodne, Jennifer J. Manly, Atul Narkhede, Erica Y. Griffith, Charles DeCarli, Nicole S. Schupf, Richard Mayeux and Adam M. Brickman
Affiliation:
关键词: 老化,认知,种族,核磁共振。
摘要: Background. Structural magnetic resonance imaging (MRI) provides key biomarkers to predict onset and track progression of Alzheimer’s disease (AD). However, most published reports of relationships between MRI variables and cognition in older adults include racially, ethnically, and socioeconomically homogenous samples. Racial/ethnic differences in MRI variables and cognitive performance, as well as health, socioeconomic status and psychological factors, raise the possibility that brain-behavior relationships may be stronger or weaker in different groups. The current study tested whether MRI predictors of cognition differ in African Americans and Hispanics, compared with non-Hispanic Whites.Methods. Participants were 638 non-demented older adults (29% non-Hispanic White, 36% African American, 35% Hispanic) in the Washington Heights-Inwood Columbia Aging Project. Composite scores of memory, language, speed/executive functioning, and visuospatial function were derived from a neuropsychological battery. Hippocampal volume, regional cortical thickness, infarcts, and white matter hyperintensity (WMH) volumes were quantified with FreeSurfer and in-house developed procedures. Multiple-group regression analysis, in which each cognitive composite score was regressed onto MRI variables, demographics, and cardiovascular health, tested which paths differed across groups. Results. Larger WMH volume was associated with worse language and speed/executive functioning among African Americans, but not among non-Hispanic Whites. Larger hippocampal volume was more strongly associated with better memory among non-Hispanic Whites compared with Hispanics. Cortical thickness and infarcts were similarly associated with cognition across groups.Conclusion. The main finding of this study was that certain MRI predictors of cognition differed across racial/ethnic groups. These results highlight the critical need for more diverse samples in the study of cognitive aging, as the type and relation of neurobiological substrates of cognitive functioning may be different for different groups.
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Laura B. Zahodne, Jennifer J. Manly, Atul Narkhede, Erica Y. Griffith, Charles DeCarli, Nicole S. Schupf, Richard Mayeux and Adam M. Brickman , Structural MRI Predictors of Late-Life Cognition Differ Across African Americans, Hispanics, and Whites, Current Alzheimer Research 2015; 12 (7) . https://dx.doi.org/10.2174/1567205012666150530203214
DOI https://dx.doi.org/10.2174/1567205012666150530203214 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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