摘要
阿尔茨海默氏病(AD)是一种与年龄相关的神经退行性疾病和老年痴呆症最常见的原因。阿尔茨海默病的病因尚不完全清楚,尽管增加的知识有关的病理机制,没有有效的疾病修饰治疗是可利用的。星形胶质细胞早期推定为神经网络只支持的作用,最近的研究表明,在突触功能障碍中发挥积极作用,损害机体,炎症以及与阿尔茨海默病病理兴奋性毒性。本文对阿尔茨海默病与星形胶质细胞的作用特别关注的病理机制,兴奋性毒性和疾病发展中的犬尿氨酸代谢的改变。在犬尿氨酸途径的保护/神经失衡的校正可能代表在神经退行性疾病相关的老年痴呆症药物治疗的新靶点。
关键词: 阿尔茨海默氏病,淀粉样蛋白,星形胶质细胞,兴奋性毒性,谷氨酸,犬尿氨酸
Current Alzheimer Research
Title:Alzheimer’s Disease, Astrocytes and Kynurenines
Volume: 12 Issue: 5
Author(s): Livia Dezsi, Bernadett Tuka, Diana Martos and Laszlo Vecsei
Affiliation:
关键词: 阿尔茨海默氏病,淀粉样蛋白,星形胶质细胞,兴奋性毒性,谷氨酸,犬尿氨酸
摘要: Alzheimer’s disease (AD) is an age-related neurodegenerative disease and the most common cause of dementia. The etiology of AD is not entirely clear and despite the increasing knowledge regarding the pathomechanism, no effective disease-modifying therapy is yet available. Astrocytes earlier presumed to serve merely supportive roles for the neuronal network, have recently been shown to play an active role in the synaptic dysfunction, impairment of homeostasis, inflammation as well as excitotoxicity in relation to AD pathology. This review focuses on the pathomechanism of AD with special attention to the role of the astrocytes, excitotoxicity and the alterations in the kynurenine metabolism in the development of the disease. The correction of the neuroprotective/neurotoxic imbalance in the kynurenine pathway may represent a novel target for pharmaceutical interventions in dementia related to neurodegenerative disorders.
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Cite this article as:
Livia Dezsi, Bernadett Tuka, Diana Martos and Laszlo Vecsei , Alzheimer’s Disease, Astrocytes and Kynurenines, Current Alzheimer Research 2015; 12 (5) . https://dx.doi.org/10.2174/156720501205150526114000
DOI https://dx.doi.org/10.2174/156720501205150526114000 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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