Abstract
1,3-dipolar cycloadditions have been studied extensively for decades. The advantages of this synthetic approach may be increased further by applying microwave irradiation. The substrates for 1,3CA reactions are particularly sensitive to microwave heating due to their dipolar nature. Furthermore, the lack of solvent effects and a catalyst that may be applied in the solid phase make these reactions even more suitable for microwave enhancement. In this review we present the advantages of microwave heating in the synthesis of nitrogen heterocycles through 1,3-dipolar cycloaddition. Although it has been studied for years, this area of synthetic chemistry still requires further elucidation.
Keywords: Azoles, azomethines, click chemistry, cycloaddition, microwave synthesis, nitrile imines.
Graphical Abstract
Current Organic Chemistry
Title:Microwave-Assisted 1,3-dipolar Cycloadditions to Nitrogen Containing Heterocycles
Volume: 19 Issue: 14
Author(s): Wioleta Cieslik, Maciej Serda and Robert Musiol
Affiliation:
Keywords: Azoles, azomethines, click chemistry, cycloaddition, microwave synthesis, nitrile imines.
Abstract: 1,3-dipolar cycloadditions have been studied extensively for decades. The advantages of this synthetic approach may be increased further by applying microwave irradiation. The substrates for 1,3CA reactions are particularly sensitive to microwave heating due to their dipolar nature. Furthermore, the lack of solvent effects and a catalyst that may be applied in the solid phase make these reactions even more suitable for microwave enhancement. In this review we present the advantages of microwave heating in the synthesis of nitrogen heterocycles through 1,3-dipolar cycloaddition. Although it has been studied for years, this area of synthetic chemistry still requires further elucidation.
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Cite this article as:
Cieslik Wioleta, Serda Maciej and Musiol Robert, Microwave-Assisted 1,3-dipolar Cycloadditions to Nitrogen Containing Heterocycles, Current Organic Chemistry 2015; 19 (14) . https://dx.doi.org/10.2174/1385272819666150518103414
DOI https://dx.doi.org/10.2174/1385272819666150518103414 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Chemistry and Biology of Carbohydrates
Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
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