阿皮卡班时代深静脉血栓形成与肺栓塞：从长凳到贝德西

Title:Deep Vein Thrombosis and Pulmonary Embolism in the Apixaban Era: From Bench to Bedside

Volume: 19 Issue: 6

关键词: 出血并发症，治疗，新的口服抗凝剂，静脉血栓形成。

摘要: Background: The traditional treatment of venous thromboembolism (VTE) with heparin and warfarin has numerous limitations. New oral anticoagulants represent the promising alternative with the potential to overcome the limitations of traditional treatment.

Objective: Apixaban is an oral factor Xa inhibitor with a rapid onset of action and predictable pharmacokinetics that allows a fixed dose regimen. With this characteristic apixaban overcomes many limitations and simplifies treatment of VTE eliminating the need for initial parenteral anticoagulant therapy and laboratory monitoring.

Results: Fixed-dose regimen of oral apixaban alone is as effective as conventional treatment regimen and is associated with a clinically relevant reduction of major bleeding. Extended anticoagulation with apixaban with either a treatment dose (5 mg twice daily) or thromboprophylactic dose (2.5 mg twice daily) reduces the risk of recurrent venous thromboembolism without increase in the rate of major bleeding.

Conclusion: Therefore, apixaban provides a simple, effective and safe alternative to conventional acute or long-term treatment of VTE.

Cite this article as:

Deep Vein Thrombosis and Pulmonary Embolism in the Apixaban Era: From Bench to Bedside, Current Drug Targets 2018; 19 (6) . https://dx.doi.org/10.2174/1389450116666150518100106