An Efficient and Environmentally Benign One-pot Three- Component Domino Protocol for the Synthesis of Structurally Diverse Spiroquinazolines

Title:An Efficient and Environmentally Benign One-pot Three- Component Domino Protocol for the Synthesis of Structurally Diverse Spiroquinazolines

Volume: 4 Issue: 3

Author(s): Sarita Khandelwal, Anshu Rajawat and Mahendra Kumar

Affiliation:

Keywords: Diversity oriented synthesis, environmentally benign synthetic protocol, spiroquinazoline-spirooxindoles, gluconic acid aqueous solution (GAAS, 50%, wt%).

Abstract: An efficient and environmentally benign diversity oriented synthetic protocol has been presented for the synthesis of structurally diverse spiroquinazolines. The hybrid druglike molecules incorporating medicinally privileged heterocyclic systems (spiroquinazolinespirooxindoles) have been synthesized by three-component reaction of isatoic anhydride, aromatic amines and substituted isatins using gluconic acid aqueous solution (GAAS, 50%, wt%) as an efficient, inexpensive and eco-friendly bio-based catalytic solvent system.

Cite this article as:

Khandelwal Sarita, Rajawat Anshu and Kumar Mahendra, An Efficient and Environmentally Benign One-pot Three- Component Domino Protocol for the Synthesis of Structurally Diverse Spiroquinazolines, Current Catalysis 2015; 4 (3) . https://dx.doi.org/10.2174/2211544704666150508221522

DOI https://dx.doi.org/10.2174/2211544704666150508221522	Print ISSN 2211-5447
Publisher Name Bentham Science Publisher	Online ISSN 2211-5455