Abstract
Voltage gated calcium channels (Cav) are composed of up to five proteins: The ion conducting pore subunit α1 and the auxiliary subunits α2, δ, β, and γ. Recent reports show that Cavα1 and Cavβ comprise the calcium channel core complex and that β, α2 δ and γ may serve additional roles that are independent of the Cavα1 subunit. This short review will summarize these emerging functions.
Keywords: Auxiliary subunits, heart, insulin secretion, neurons, non-smooth muscle cells, pain perception voltage-gated calcium channel.
Graphical Abstract
Current Molecular Pharmacology
Title:Emerging Alternative Functions for the Auxiliary Subunits of the Voltage- Gated Calcium Channels
Volume: 8
Author(s): Franz Hofmann, Anouar Belkacemi and Veit Flockerzi
Affiliation:
Keywords: Auxiliary subunits, heart, insulin secretion, neurons, non-smooth muscle cells, pain perception voltage-gated calcium channel.
Abstract: Voltage gated calcium channels (Cav) are composed of up to five proteins: The ion conducting pore subunit α1 and the auxiliary subunits α2, δ, β, and γ. Recent reports show that Cavα1 and Cavβ comprise the calcium channel core complex and that β, α2 δ and γ may serve additional roles that are independent of the Cavα1 subunit. This short review will summarize these emerging functions.
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Cite this article as:
Hofmann Franz, Belkacemi Anouar and Flockerzi Veit, Emerging Alternative Functions for the Auxiliary Subunits of the Voltage- Gated Calcium Channels, Current Molecular Pharmacology 2015; 8 (2) . https://dx.doi.org/10.2174/1874467208666150507110202
DOI https://dx.doi.org/10.2174/1874467208666150507110202 |
Print ISSN 1874-4672 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-4702 |
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